Dr Dan Ma

Dan Ma photo for webpage s  
  • Position: Research Fellow and Deputy Director of Regenerative Medicine Centre
  • Telephone: 0121 204 4526
  • Email: d.ma@aston.ac.uk
  • Room Number: MB314C

 

 

Dan Ma studied medicine and obtained her MD in China, then worked as a university lecturer in the medical school, teaching histology and embryology whilst performing research. She came to the UK as a Royal Society Visiting Fellow at University of Nottingham, following which she completed her D.Phil on neuroanatomy at the University of Oxford. She later moved to the University of Cambridge to continue biomedical research on various subjects including diabetes, mental diseases, epigenetics and neural degeneration. While working in the Cambridge Stem Cell Institute and the Department of Clinical Neurosciences for 8 years, she focused on the projects in regenerative medicine in the central nervous system (CNS), especially the adult stem cells mediated CNS remyelination. She also carried out the study on human iPSC derived neural stem cells (NSC), oligodendrocyte progenitor cells (OPC), and endothelial progenitor cells (EPC), for their potential in clinical application. In 2018, she joined AMS as a research fellow and the Deputy Director of Regenerative Medicine Centre. She is interested in the research exploring the mechanisms of cell-cell interaction, disease modelling and therapeutic potential of iPSC-derived cells in neurodegenerative diseases.

  • D.Phil. The University of Oxford, 1999
  • Master of Medicine (MD) The Fourth Military Medical University, Xi’an, PR China, 1989
  • Bachelor of Medicine and Bachelor of Surgery (MBBS) The Fourth Military Medical University, Xi’an, PR China, 1986
  • Human iPSC derived cells in the study and clinical application for neurodegenerative diseases
  • Remyelination following injury and diseases
  • Adult neural stem cells mediated regenerative process
Beijing Allife Medical Biotechnology (2018-)

Selected publications:

Dan Ma*, Bowei Wang*, Malgorzata Zawadzka, Ginez Gonzalez, Zhaozong Wu, Bin Yu, Emma Rawlins, Robin Franklin, and Chao Zhao A sub-population of Foxj1 expressing, non-myelinating Schwann cells of the peripheral nervous system contribute to Schwann cell remyelination in the central nervous system. J Neurosci. 2018 Sep 18. pii: 0585-18. *same contribution

Moyon S*, Ma D*, Huynh JL, Coutts DJC, Zhao C, Casaccia P, Franklin RJM. Efficient Remyelination Requires DNA Methylation. eNeuro 2017 Mar 30; 4(2): pii: ENEURO.0336-16

Chong CM, Ma D, Zhao C, Franklin RJ, Zhou ZY, Ai N, Li C, Yu H, Hou T, Sa F, Ming-Yuen Lee S Discovery of a novel neuroprotectant, BHDPC, that protects against MPP(+)/MPTP-induced neuronal death in multiple experimental models. Free Radic Biol Med. 2015 Dec; 89:1057-66.

Zhao C, Ma D, Zawadzka M, Fancy SP, Elis-Williams L, Bouvier G, Stockley JH, de Castro GM, Wang B, Jacobs S, Casaccia P, Franklin RJ. Sox2 Sustains Recruitment of Oligodendrocyte Progenitor Cells following CNS Demyelination and Primes Them for Differentiation during Remyelination. J Neurosci. 2015 Aug 19;35(33):11482-99.

Dan Ma, Paul C Guest & Sabine Bahn Metabonomic studies of schizophrenia and psychotropic medications: focus on alterations in CNS energy homeostasis (review) Bioanalysis December 2009, Vol. 1, No. 9, Pages 1615-1626.

Ma D*, Chan MK*, Lockstone HE, Pietsch SR, Jones DN, Cilia J, Hill MD, Robbins MJ, Benzel IM, Umrania Y, Guest PC, Levin Y, Maycox PR, Bahn S. Antipsychotic treatment alters protein expression associated with presynaptic function and nervous system development in rat frontal cortex. J Proteome Res. 2009 Jul;8(7):3284-97.

McLoughlin GA*, Ma D*, Tsang TM, Jones DN, Cilia J, Hill MD, Robbins MJ, Benzel IM, Maycox PR, Holmes E, Bahn S. Analyzing the effects of psychotropic drugs on metabolite profiles in rat brain using 1H NMR spectroscopy. J Proteome Res.2009 Apr;8(4):1943-52.

Ma D, Shield JP, Dean W, Leclerc I, Knauf C, Burcelin R R, Rutter GA, Kelsey G. Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM.J Clin Invest. 2004 Aug;114(3):339-48

Ma D, Allen ND, Van Bergen YC, Jones CM Baum M, Keverne EB and Brennan PA: Selective ablation of olfactory receptor neurons without functional impairment of vomeronasal receptor neurons in OMP-ntr transgenic mice. Eur J Neurosci 2002 Dec;16(12):2317-23

Ma D and Morris JF: Protein Synthetic Machinery in the Dendrites of the Magnocellular Neurosecretory Neurons of Wild-type Long-Evans and Homozygous Brattleboro Rats. J Chem Neuroanat. 2002 Mar; 23(3):171-86.

Isles A*, Ma D*, Milson C, Cui W, Skynner M, Keverne EB and Allen ND: Conditional ablation of olfactory receptor neurons in transgenic mice: a complementation strategy to study olfaction of mutant cells. J Neurobiol. 2001 Jun 5;47(3):183-93.

Isles A, Baum M, Ma D, Keverne EB and Allen ND: Urinary odour preferences in mice. Nature. 2001 Feb 15;409(6822):783-4.

Ma D, Zhao C, Mayhew T and Ju G: Response of Substance-P immunoreactivity nerve fibres in the anterior pituitary to plasma estrogen level in the rat. J Endocrinol  1997. 9:735-740,