Dr. Ioannis Kyrou

Ioannis

I have joined Aston Medical School in 2014 as a Clinical Lecturer (Assistant Professor) in Metabolic Medicine and Nutrition. Overall, I have more than 15 years of research experience in the field of metabolism, nutrition, exercise and endocrinology. I have been responsible for multiple clinical and basic research studies focused in these subjects, whilst I have also been an investigator in several relevant clinical trials. My teaching and research focus on metabolism, nutrition, exercise, obesity, diabetes, cardiovascular disease, non-alcoholic fatty liver disease, polycystic ovary syndrome, public health and chronic stress.

My current clinical and translational research projects aim to further explore the pathophysiology of these chronic non-communicable diseases, identify novel related biomarkers and test new interventions. To date, the research output of my previous and ongoing research projects has resulted in important publications in peer-reviewed medical journals (more than 40 published peer-reviewed papers in PubMed with more than 2500 citations based on Google Scholar), as well as in numerous announcements in national and international biomedical congresses (more than 50 abstracts/posters/presentations at scientific conferences). In addition, I have also authored more than 20 chapters published in high-impact biomedical textbooks.

  • Medical Diploma (First-class honours), Athens Medical School, University of Athens, Greece (2001)
  • PhD in Medicine, Warwick Medical School, University of Warwick, UK (2013)
  • Post-graduate Certificate in Learning and Teaching in Higher Education (Distinction), Aston University, Birmingham, UK (2015)
  • Post-graduate Diploma in Learning and Teaching in Higher Education (Distinction), Aston University, Birmingham, UK (2016)
  • Masters in Education (M.Ed.) (Distinction), Aston University, Birmingham, UK (2018)

2013– Honorary Clinical Lecturer, Division of Metabolic & Vascular Health, Warwick Medical School, University of Warwick, UK.

2016–2018: Honorary Senior Research Fellow, Centre for Applied Biological & Exercise Sciences, Faculty of Health & Life Sciences, Coventry University, UK.

2007– Endocrinology Fellow, University Hospital Coventry and Warwickshire NHS Trust, Coventry, UK.

2007–2012: PhD in Medicine, Warwick Medical School, University of Warwick, UK.

My teaching subjects focus on the following:

  • Human metabolism, metabolic medicine and endocrinology
  • Nutrition
  • Exercise and health
  • Epidemiology of chronic non-communicable diseases (e.g. obesity, diabetes, cardiovascular disease and mental health disorders such as stress) and their consequences on public health.

My research projects focus on the following:

  • Metabolism and energy homeostasis 
  • Nutrition 
  • Exercise and health 
  • Epidemiology of non-communicable diseases and public health 
  • Obesity and obesity-related complications 
  • Type 2 diabetes 
  • Cardiovascular diseases 
  • Endocrinology 
  • Polycystic ovary syndrome (PCOS) 
  • Non-alcoholic fatty liver disease (NAFLD) 
  • Mental health - Stress and the HPA axis  

 

Novel biomarkers/adipokines and the adipocyte secretome contributing to increased cardiovascular risk in obesity-related diabetes - effects of nutrition and exercise”, funded by the Aston University 50th Anniversary Prize PhD Studentships Scheme. 

“Effects of bariatric surgery on metabolic improvement and remission of T2DM”, funded by the EFSD. 

“Effects of obesity on functional limitations and disability”, funded by the DWP. 

My current PhD projects at Aston University focus on the pathophysiology of obesity, type 2 diabetes and other obesity-related diseases (e.g. PCOS, CVD), particularly in relationship with nutrition and exercise:

  • “Novel biomarkers and adipose tissue secreted factors associated with increased cardiovascular risk in obesity and diabetes - effects of nutrition and exercise”
  • “The effectiveness of exercise in the management of polycystic ovary syndrome.

Potential candidates for a research PhD at Aston University are welcomed to contact me with an idea or a fully developed proposal for a research project in the following fields: metabolism and energy homeostasis, nutrition, exercise and health, public health and epidemiology of non-communicable diseases, obesity and obesity-related complications (e.g. type 2 diabetes, cardiovascular disease), polycystic ovary syndrome, non-alcoholic fatty liver disease, mental health and stress.

  • General Medical Council
  • Higher Education Academy (Fellow of HEA)
  • Society for Endocrinology, UK
  • Association for the Study of Obesity, UK
  • British Association of Sport and Exercise Sciences, UK
  • Hellenic Atherosclerosis Society, Greece
  • European Association for the Study of Obesity
  • European Association for the Study of Diabetes.

 

 Selected original research articles:

  • Weickert MO, Hattersley JG, Kyrou I, Arafat AM, Rudovich N, Roden M, Nowotny P, von Loeffelholz C, Matysik S, Schmitz G, Pfeiffer AFH. Effects of supplemented isoenergetic diets varying in cereal fiber and protein content on the bile acid metabolic signature and relation to insulin resistance. Nutrition & Diabetes. 2018 Mar 7;8(1):11. doi: 10.1038/s41387-018-0020-6. 
  • Jackisch L, Kumsaiyai W, Moore JD, Al-Daghri N, Kyrou I, Barber TM, Randeva H, Kumar S, Tripathi G, McTernan PG. Differential expression of Lp-PLA2 in obesity and type 2 diabetes and the influence of lipids. Diabetologia. 2018 May;61(5):1155-1166. doi: 10.1007/s00125-018-4558-6. 
  • Kahal H, Kyrou I, Uthman O, Brown A, Johnson S, Metcalfe P, Tahrani A, Randeva H. The Association between Obstructive Sleep Apnoea and Metabolic Abnormalities in Women with Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis. Sleep, 2018 zsy085, https://doi.org/10.1093/sleep/zsy085 
  • Kyrou I, Tsantarlioti O, Panagiotakos DB, Tsigos C, Georgousopoulou E, Chrysohoou C, Skoumas I, Tousoulis D, Stefanadis C, Pitsavos C; ATTICA study group. Adiponectin circulating levels and 10-year (2002-2012) cardiovascular disease incidence: the ATTICA Study. Endocrine. 2017 Dec;58(3):542-552. 
  • Rana KS, Pararasa C, Afzal I, Nagel DA, Hill EJ, Bailey CJ, Griffiths HR, Kyrou I, Randeva HS, Bellary S, Brown JE. Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels. Cardiovascular Diabetology. 2017 Nov 9;16(1):147. 
  • Kouli GM, Panagiotakos DB, Kyrou I, Magriplis E, Georgousopoulou EN, Chrysohoou C, Tsigos C, Tousoulis D, Pitsavos C. Olive oil consumption and 10-year (2002-2012) cardiovascular disease incidence: the ATTICA study. European Journal of Nutrition. 2017 Nov 9. doi: 10.1007/s00394-017-1577-x. 
  • Weickert MO, Kyrou I. Letter on: Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism. New England Journal of Medicine. 2017 Oct 5;377(14):e20. 
  • Kouli GM, Panagiotakos DB, Kyrou I, Georgousopoulou EN, Chrysohoou C, Tsigos C, Tousoulis D, Pitsavos C. Visceral adiposity index and 10-year cardiovascular disease incidence: The ATTICA study. Nutrition, Metabolism and Cardiovascular Diseases. 2017 Oct;27(10):881-889. 
  • Kyrou I, Christou A, Panagiotakos D, Stefanaki C, Skenderi K, Katsana K, Tsigos C. Effects of a hops (Humulus lupulus L.) dry extract supplement on self-reported depression, anxiety and stress levels in apparently healthy young adults: a randomized, placebo-controlled, double-blind, crossover pilot study. Hormones (Athens). 2017 Apr;16(2):171-180. 
  • Kahal H, Kyrou I, Tahrani AA, Randeva HS. Obstructive sleep apnoea and polycystic ovary syndrome: A comprehensive review of clinical interactions and underlying pathophysiology. Clin Endocrinol (Oxf). 2017 Oct;87(4):313-319. 
  • Filippatos TD, Kyrou I, Georgousopoulou EN, Chrysohoou C, Kouli GM, Tsigos C, Tousoulis D, Stefanadis C, Pitsavos C, Panagiotakos DB. Modeling anthropometric indices in relation to 10-year (2002-2012) incidence of cardiovascular disease, among apparently healthy individuals: The ATTICA study. Diabetes Metab Syndr. 2017 Dec;11 Suppl 2:S789-S795. 
  • Martinez de la Escalera L, Kyrou I, Vrbikova J, Hainer V, Sramkova P, Fried M, Piya MK, Kumar S, Tripathi G, McTernan PG. Impact of gut hormone FGF-19 on type-2 diabetes and mitochondrial recovery in a prospective study of obese diabetic women undergoing bariatric surgery. BMC Medicine. 2017 Feb 16;15(1):34. doi: 10.1186/s12916-017-0797-5. 
  • Vrbikova J, Kunesova M, Kyrou I, Tura A, Hill M, Grimmichova T, Dvorakova K, Sramkova P, Dolezalova K, Lischkova O, Vcelak J, Hainer V, Bendlova B, Kumar S, Fried M. Insulin sensitivity and secretion in obese type 2 diabetic women after various bariatric operations. Obesity Facts. 2016;9(6):410-23. 
  • Kyrou I, Kollia N, Panagiotakos D, Georgousopoulou E, Chrysohoou C, Tsigos C, Randeva HS, Yannakoulia M, Stefanadis C, Papageorgiou C, Pitsavos C; ATTICA Study investigators. Association of depression and anxiety status with 10-year cardiovascular disease incidence among apparently healthy Greek adults: The ATTICA Study. European Journal of Preventive Cardiology. 2017 Jan;24(2):145-152. 
  • Kyritsi EM, Dimitriadis GK, Kyrou I, Kaltsas G, Randeva HS. PCOS remains a diagnosis of exclusion: a concise review of key endocrinopathies to exclude. Clin Endocrinol (Oxf). 2017 Jan;86(1):1-6. 
  • Dimitriadis GK, Kyrou I, Randeva HS. Polycystic Ovary Syndrome as a Proinflammatory State: The Role of Adipokines. Curr Pharm Des. 2016;22(36):5535-5546. 
  • Kyrou I, Weickert MO, Gharanei S, Randeva HS, Tan BK. Fibroblast growth factors: new insights, new targets in the management of diabetes. Minerva Endocrinol. 2017 Sep;42(3):248-270. doi: 10.23736/S0391-1977.16.02536-0. 
  • Hu J, Kyrou I, Tan BK, Dimitriadis GK, Ramanjaneya M, Tripathi G, Patel V, James S, Kawan M, Chen J, Randeva HS. Short-chain fatty acid acetate stimulates adipogenesis and mitochondrial biogenesis via GPR43 in brown adipocytes. Endocrinology. 2016 Mar 18:en20151944. 
  • Esfahani S, Sagar NM, Kyrou I, Mozdiak E, O'Connell N, Nwokolo C, Bardhan KD, Arasaradnam RP, Covington JA. Variation in Gas and Volatile Compound Emissions from Human Urine as It Ages, Measured by an Electronic Nose. Biosensors (Basel). 2016 Jan 25;6(1). pii: E4. 
  • Bradnova O*, Kyrou I* [*: joint first authors], Hainer V, Vcelak J, Halkova T, Sramkova P, Dolezalova K, Fried M, McTernan P, Kumar S, Hill M, Kunesova M, Bendlova B, Vrbikova J. Laparoscopic greater curvature plication in morbidly obese women with type 2 diabetes: effects οn glucose homeostasis, postprandial triglyceridemia and selected gut hormones. Obesity Surgery. 2014 May;24(5):718-26. 
  • Kyrou I, Osei-Assibey G, Williams N, Thomas R, Halder L, Taheri S, Saravanan P, Kumar S. Self-reported disability in adults with severe obesity. J Obes. 2012;2011:918402. doi: 10.1155/2011/918402. 
  • Osei-Assibey G, Adi A, Kyrou I, Kumar S, Matyka K. Pharmacotherapy for overweight/obesity in ethnic minorities and white Caucasians: a systematic review. Diabetes Obes Metab. 2011 May; 13(5):385-93. 
  • Arasaradnam RP, Quraishi N, Kyrou I, Nwokolo CU, Joseph M, Kumar S, Bardhan KD, Covington JA. Insights into 'fermentonomics': evaluation of VOCs in human disease using an electronic 'e-nose'. J Med Eng Technol. 2011 Feb; 35(2):87-91. 
  • Osei-Assibey G, Kyrou I, Kumar S, Saravanan P, Matyka KA. Self-Reported Psychosocial Health in Obese Patients before and after Weight Loss. J Obes. 2010; 2010. doi: pii: 372463. 10.1155/2010/372463. 
  • Kyrou I, Kumar S. Weight management in overweight and obese patients with type 2 diabetes mellitus. The British Journal of Diabetes & Vascular Disease 2010; 10: 274-283. 
  • Osei-Assibey G, Kyrou I, Adi A, Kumar S, Matyka K. Dietary and lifestyle interventions for weight management in adults from minority ethnic/non-White groups: a systematic review. Obesity Reviews. 2010 Nov; 11(11):769-76. 
  • Kyrou I, Tsigos C. Stress hormones: physiological stress and regulation of metabolism. Curr Opin Pharmacol. 2009 Dec; 9(6):787-93. 
  • Kyrou I, Tsigos C. Obesity in the elderly diabetic patient – is weight loss beneficial? Diabetes Care, 2009 Nov; 32 Suppl 2:S403-9. 
  • Tsiotra PC, Tsigos C, Anastasiou E, Yfanti E, Boutati E, Souvatzoglou E, Kyrou I, Raptis SA. Peripheral mononuclear cell resistin mRNA expression is increased in type 2 diabetic women. Mediators Inflamm. 2008; 2008:892864. 
  • Kyrou I, Tsigos C. Chronic stress, visceral obesity and gonadal dysfunction. Hormones. 2008; 7(4):287-93. 
  • Kyrou I, Tsigos C. Stress mechanisms and metabolic complications. Hormone and Metabolic Research, 2007; 39(6): 430-8. 
  • Kyrou I, Valsamakis G, Tsigos C. Endocannabinoid system as a target for the treatment of visceral obesity & metabolic syndrome. Annals of New York Academy of Sciences, 2006; 1083: 270-305. 
  • Kyrou I, Chrousos GP, Tsigos C. Stress, Visceral Obesity, and Metabolic Complications. Annals of New York Academy of Sciences, 2006; 1083: 77-110. 
  • Kyrou I, Tsigos C. Hypothalamic-Pituitary-Adrenal Axis, Cytokines and Metabolic Syndrome. Obesity and Metabolism, 2006 Jun; Vol. 2, No. 2:116-126. 
  • Papanicolaou DA, Mullen N, Kyrou I, Nieman LK. Night-time salivary cortisol: a useful test for the diagnosis of Cushing's syndrome. Journal of Clinical Endocrinology & Metabolism, 2002; 87(10):4515-21. 
  • Tsigos C, Kyrou I, Raptis S. Monogenic Forms of Obesity and Diabetes Mellitus. Journal of Pediatric Endocrinology & Metabolism, 2002 Mar; 15(3):241-53. 
  • Fotiadis C, Sergiou C, Kyrou I [cited as Kirou J], Troupis T, Tselentis J, Doussaitou P, Gorgoulis G, Sechas MN. Experimental Echinococcus infection in the mouse model: pericystic cellular immunity reaction and effects on the lymphoid organs of immunocompetent and thymectomized mice. In Vivo 1999 Nov-Dec 13(6):541-6. 
  • Tsigos C, Papanicolaou DA, Kyrou I, Chrousos GP. Dose-Effects of Recombinant Human Interleukin-6 on the Pituitary-Testicular Axis. Journal of Interferon and Cytokine Research, 1999; Nov 19(11):1271-6. 
  • Tsigos C, Kyrou I, Chala E, Tsapogas P, Stauridis I, Raptis S, Katsilambros N. Circulating TNF-a Concentrations are Higher in Abdominal Versus Peripheral Obesity. Metabolism, 1999; Oct 48(10):1332-5. 
  • Tsigos C, Kyrou I, Chrousos GP, Papanicolaou DA. Prolonged suppression of corticosteroid-binding globulin recombinant human IL-6 in man. Journal of Clinical Endocrinology and Metabolism, 1998; 83: 3379. 
  • Tsigos C, Papanicolaou DA, Kyrou I, Defensor R, Mitsiadis C, Chrousos GP. Dose-Effects of Recombinant Human Interleukin-6 (IL-6) on Glucose Regulation. Journal of Clinical Endocrinology and Metabolism, 1997; 82: 4167-4170. 
  • Tsigos C, Papanicolaou DA, Defensor R, Mitsiadis C, Kyrou I, Chrousos GP. Dose-Effects of Recombinant Human Interleukin-6 (IL-6) on Pituitary Hormone Secretion and Energy Expenditure. Neuroendocrinology, 1997; 66: 54-62.  

 
Selected academic book chapters:

  • Kyrou I, Randeva H, Tsigos C, Kaltsas G, Weickert MO. Clinical problems caused by obesity. In: Purnell J, Perreault L (Eds), Obesity.   (http://www.endotext.org/section/obesity/) 3rd edition Endotext.org, MDTEXT.COM, INC, S. Dartmouth, MA, 2018.
  • Kyrou I, Randeva H, Tsigos C. Stress, Insulin Resistance and Type II Diabetes. In George Fink (ed); Stress: Neuroendocrinology and Neurobiology, Academic Press, San Diego, 2017.
  • Tsigos C, Kyrou I, Kassi E, Chrousos GP. Stress Endocrine Physiology and Pathophysiology. In: Chrousos GP (Ed), Adrenal Disease and Function (http://www.endotext.org/section/adrenal/) 3rd edition Endotext.org, MDTEXT.COM, INC, S. Dartmouth, MA, 2016.
  • Kyrou I, Mattu H, Chatha K, Randeva H. Fat hormones, adipokines. In Schisler JC, Lang CH, Willis M (eds); Endocrinology of the Heart in Health and Disease. Academic Press, 11 Nov 2016. 1st Edition. www.sciencedirect.com/science/book/9780128031117
  • Kyrou I, Weickert MO, Randeva H. Diagnosis and Management of PCOS. In: Ajjan R. (Eds), Endocrinology & Diabetes: Case Studies, Questions & Commentaries. Springer, UK, 2014.
  • Kyrou I, Haukeland JW, Bhala N, Kumar S.: Metabolic syndrome, diabetes and NASH. In: Kopelman P, Caterson I, Dietz W. (Eds), Clinical Obesity in Adults & Children, 3rd Ed. Wiley-Blackwell, Oxford, UK, 2010.
  • Kyrou I, Tsigos C.: HPA Axis, adipose tissue and the metabolic syndrome. In: Seminars in Endocrinology: Hypothalamic-Pituitary-Adrenal Axis. Published by the Hellenic Endocrinology Association, Athens, Greece, 2007.
  • Tsigos C, Kyrou I.: Stress, Insulin Resistance and Type II Diabetes. In: Fink G. (Ed), Encyclopedia of Stress, 2nd edition, Academic Press, San Diego, USA, 2007.
  • Tsigos C, Kyrou I.: Hypothalamic-Pituitary-Adrenal Axis interactions with inflammatory cytokines and the metabolic syndrome. In: Seminars in Endocrinology: Metabolic Syndrome. Published by the Hellenic Endocrinology Association, Athens, Greece, 2006.
  • Kyrou I, Tsigos C.: Hypothalamic-Pituitary-Adrenal Axis. In: van Heerden J, Linos D (Eds), Adrenal Glands: Diagnostic Aspects and Surgical Therapy, Springer-Verlag, Berlin and Heidelberg, Germany, 2005.
  • Tsigos C, Kyrou I.: Molecular actions of the thyroid hormones. Thyroid receptors and thyroid hormone resistance syndromes. In: Seminars in Endocrinology: Thyroid. Published by the Hellenic Endocrinology Association, Athens, Greece, 2004.
  • Tsigos C, Kyrou I, Chrousos GP.: Stress, endocrine manifestations and diseases: The research and the practice. In: Cooper GL (Ed), Handbook of Stress Medicine and Health, 2nd Edition, CRC Press, Boca Barton, Florida, USA, 2004.
  • Tsigos C, Kyrou I.: Obesity and the gonadal axis. In: Panidis D. (Ed), Endocrinology of reproduction, Published by the Hellenic Endocrinology Association, Athens, Greece, 2004.
  • Tsigos C, Kyrou I.: Neuroendocrine regulation of metabolism. In: Seminars in Endocrinology: Neuroendocrinology, Published by the Hellenic Endocrinology Association, Athens, Greece, 2003.