Dr Lissette Sanchez-Aranguren

Lizette Sanchez Aranguren 
  • Position:  Aston Prize Fellow/Postdoctoral Research Fellow
  • Telephone: 01212045052
  • Email: l.sanchez-aranguren2@aston.ac.uk
  • Room Number: MB319
 

 

I joined Aston University in August 2018 awarded with the 50th Anniversary Prize Fellowship that provides two years funding for a Research Fellow, with academic excellence being the primary criterion. During my PhD, I focused on the study of real time cellular bioenergetics and metabolic phenotyping of endothelial and trophoblasts cells exposed to conditions that resemble preeclamptic phenotype. Preeclampsia is a life-threatening disease that affect 1 in 12 of all pregnancies worldwide and is considered  the  most  enigmatic  hypertensive  pregnancy-specific  disorder,  contributing  to  over 76,000  maternal  and  500,000 infant deaths annually. As part of the Aston Medical School, I will work in concert with a team of postdoctoral fellows in order to investigate the role of cellular bioenergetics and metabolism linked to gasotransmitters in maternal vascular disorders.

  • 2013 – 2017  Ph.D. in Biomedical Sciences. Universidad del Valle, Cali, Colombia.
  • 2012 – 2013. Postgraduate Diploma in Business Management. Universitat Politécnica de Valencia, Valencia, Spain.
  • 2012 – 2013. Postgraduate Diploma in Management of Health Services. Universidad de Santander, Bucaramanga, Colombia.
  • 2010 – 2010  Certification in Education/Teaching for graduate students. Universidad de Carabobo FUNDAUC, Venezuela.
  • 2005 – 2009  Bachelor of Science (Clinical Laboratory Sciences) Universidad de Carabobo, Venezuela.
  • 2017 –  2018 Postdoctoral Research Fellow. Advanced Therapy Center, Multi-Tissue Bank, Fundacion Oftalmologica de Santander – Carlos Ardila Lulle (FOSCAL) Bucaramanga, Santander, Colombia.
  • 2013 – 2017 Research Assistant. Cardiovascular Foundation of Colombia, Department of Biotechnology, Bucaramanga, Santander, Colombia.
  • 2009 – 2011 Project Assistant. Centro de Biología Molecular de Parásitos (BioMolP), Health Faculty, Universidad de Carabobo, Bárbula, Venezuela.
  • 2009 – 2011 Clinical and Molecular Laboratory Scientist. Specialized Laboratories, Laboratorio Clinico Galeno, Valencia, Venezuela.

My research is focused on understanding the role of cellular bioenergetics and mitochondrial metabolism in physiological and pathological conditions, in order to identify potential metabolic targets for pharmacological intervention.

My experience in cellular bioenergetics have been focused on understanding the molecular mechanisms that lead to the onset of preeclampsia from a cellular metabolic perspective. Key proteins of interest in the disorder are vascular endothelial growth factor and its antagonist, the soluble form of vascular endothelial growth factor receptor 1 (sFlt-1). My research is currently aimed to understand the molecular mechanisms by which up-regulated sFlt-1 induces vascular dysfunction and its effect over the mitochondrial bioenergetics, oxidative and nitrosative stress, metabolic phenotype and fuel dependency and flexibility.
  • Administrative Department of Science, Technology and Innovation (Colciencias) 2017- 2018
  • Universidad Católica de Manizales (Colombia) 2017 - 2018
  • Universidad del Rosario (Colombia) 2018
  • Sánchez-Aranguren LC, Espinosa-González CT, González-Ortiz LM, Sanabria-Barrera SM, Riaño-Medina CE, Nuñez AF, Ahmed A, Vasquez-Vivar J, López M. Soluble Fms-Like Tyrosine Kinase-1 Alters Cellular Metabolism and Mitochondrial Bioenergetics in Preeclampsia. Frontiers in Physiology. 2018 Mar 6;9:83.
  • Sanchez-Aranguren LC, Prada CE, Riano-Medina CE, Lopez M. Endothelial Dysfunction and Preeclampsia: Role of Oxidative Stress. Frontiers in Physiology. 2014;5:372.
  • Barrios E, Rodríguez J, Richani N, Araque W, Quintana JF, Sánchez L. Effect of Treatment with Praziquantel on the activity of alkaline phosphatase acid phosphatase, superoxide dismutase in Crude Extracts and Excretion-secretion Products of Schistosoma mansoni worms. Revista Salus. 2013; Vol 17:44-53
  • Hernández A, Barrios E, Sánchez L, Araque W, Delgado V. Morphological types, number of parasites per field and parasite load of Blastocystis sp from symptomatic and asymptomatic patients. Revista Salus. 2012: Vol 16;15-25.
  • Querales, MI, Cruces ME, Sánchez LC, Querales M, Rojas S, Sánchez L. Measurement of cholesterol low-density lipoprotein using three methodologies. Bioquímica Clínica. 2012;46(1)31-7. 
  • Querales MI, Cruces ME, Rojas S, Sánchez L. Association Between Vitamin D Deficiency and Metabolic Syndrome. Revista Médica de Chile. 2010;138:1312-1318.