I completed my BSc (Hons) Biochemistry at Newcastle University in 2004 before taking up a PhD studentship with Prof John Hesketh (Newcastle University) investigating how manipulation of the 3’UTR of a cloned gene could lead to increased recombinant protein production in mammalian cell factories. In 2009 I moved to the University of Birmingham where I stayed until 2018. During my time at UoB I completed three Post-Doctoral Research Fellow positions under Prof Karim Raza, Prof Janet Lord and Dr Simon Jones. My research focussed on the drivers of inflammation in the joints of osteoarthritis (OA) patients, with a focus on the relationship between obesity and a severe inflammatory pathology in OA. More latterly, my interest surrounded the role of long non-coding RNAs (lncRNAs) in the modulation of gene expression in OA joint tissues which contributed to an inflammatory phenotype in these patients. In addition to these areas, I developed a keen interest in the interaction of biomaterials with the immune system which stemmed from early catastrophic failure of metal-on-metal total hip implants. In 2017, I took up a Teaching Fellow position in the School of Pharmacy, University of Birmingham, where I gained invaluable experience in curriculum design and delivery. I briefly returned to the lab in early 2018 to investigate the phenotype of osteoblasts from different regions of the spinal curve in scoliosis patients before moving to Aston University in March 2018 where I am currently a Teaching Fellow in Aston Medical School.
Pearson, M. J., Bik, M. A., Ospelt, C., Naylor, A., Wehmeyer, C., Jones, S. W., . . . Lord, J. M. (2018). Endogenous Galectin-9 suppresses apoptosis in human rheumatoid arthritis synovial fibroblasts. Sci Rep. (In Press)
Pearson, M. J., Herndler-Brandstetter, D., Tariq, M. A., Nicholson, T. A., Philp, A. M., Smith, H. L., . . . Lord, J. M. (2017). IL-6 secretion in osteoarthritis patients is mediated by chondrocyte-synovial fibroblast cross-talk and is enhanced by obesity. Sci Rep, 7(1), 3451. doi:10.1038/s41598-017-03759-w
Pearson, M. J., Grover, L. M., Lord, J. M., Jones, S. W., & Davis, E. T. (2017). Bearings in Hip Arthroplasty: Joint Registries vs Precision Medicine: Review Article. HSS J, 13(1), 20-27. doi:10.1007/s11420-016-9531-7
Cooke, M. E., Pearson, M. J., Moakes, R. J. A., Weston, C. J., Davis, E. T., Jones, S. W., & Grover, L. M. (2017). Geometric confinement is required for recovery and maintenance of chondrocyte phenotype in alginate. APL Bioengineering, 1(1), 016104. doi:10.1063/1.5006752
Pearson, M. J., Philp, A. M., Heward, J. A., Roux, B. T., Walsh, D. A., Davis, E. T., . . . Jones, S. W. (2016). Long Intergenic Noncoding RNAs Mediate the Human Chondrocyte Inflammatory Response and Are Differentially Expressed in Osteoarthritis Cartilage. Arthritis Rheumatol, 68(4), 845-856. doi:10.1002/art.39520
Pearson, M. J., & Jones, S. W. (2016). Review: Long Noncoding RNAs in the Regulation of Inflammatory Pathways in Rheumatoid Arthritis and Osteoarthritis. Arthritis Rheumatol, 68(11), 2575-2583. doi:10.1002/art.39759
Hardy, R. S., Doig, C. L., Hussain, Z., O'Leary, M., Morgan, S. A., Pearson, M. J., . . . Raza, K. (2016). 11beta-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation. J Pathol, 240(4), 472-483. doi:10.1002/path.4806
Spengler, J., Lugonja, B., Ytterberg, A. J., Zubarev, R. A., Creese, A. J., Pearson, M. J., . . . Scheel-Toellner, D. (2015). Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid. Arthritis Rheumatol, 67(12), 3135-3145. doi:10.1002/art.39313
Pearson, M. J., Williams, R. L., Floyd, H., Bodansky, D., Grover, L. M., Davis, E. T., & Lord, J. M. (2015). The effects of cobalt-chromium-molybdenum wear debris in vitro on serum cytokine profiles and T cell repertoire. Biomaterials, 67, 232-239. doi:10.1016/j.biomaterials.2015.07.034
Filer, A., Antczak, P., Parsonage, G. N., Legault, H. M., O'Toole, M., Pearson, M. J., . . . Falciani, F. (2015). Stromal transcriptional profiles reveal hierarchies of anatomical site, serum response and disease and identify disease specific pathways. PLoS ONE, 10(3), e0120917. doi:10.1371/journal.pone.0120917
Tonge, D. P., Pearson, M. J., & Jones, S. W. (2014). The hallmarks of osteoarthritis and the potential to develop personalised disease-modifying pharmacological therapeutics. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, 22(5), 609-621. doi:10.1016/j.joca.2014.03.004
Khaziapoul, S., Pearson, M. J., Pryme, I. F., Stern, B., & Hesketh, J. E. (2012). CUG binding protein 1 binds to a specific region within the human albumin 3' untranslated region. Biochem Biophys Res Commun, 426(4), 539-543. doi:10.1016/j.bbrc.2012.08.123
Google Scholar: https://scholar.google.co.uk/citations?hl=en&user=Swqq05IAAAAJ
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