Dr Mark J Pearson

Mark Pearson  

 

I completed my BSc (Hons) Biochemistry at Newcastle University in 2004 before taking up a PhD studentship with Prof John Hesketh (Newcastle University) investigating how manipulation of the 3’UTR of a cloned gene could lead to increased recombinant protein production in mammalian cell factories. In 2009 I moved to the University of Birmingham where I stayed until 2018. During my time at UoB I completed three Post-Doctoral Research Fellow positions under Prof Karim Raza, Prof Janet Lord and Dr Simon Jones. My research focussed on the drivers of inflammation in the joints of osteoarthritis (OA) patients, with a focus on the relationship between obesity and a severe inflammatory pathology in OA. More latterly, my interest surrounded the role of long non-coding RNAs (lncRNAs) in the modulation of gene expression in OA joint tissues which contributed to an inflammatory phenotype in these patients. In addition to these areas, I developed a keen interest in the interaction of biomaterials with the immune system which stemmed from early catastrophic failure of metal-on-metal total hip implants. In 2017, I took up a Teaching Fellow position in the School of Pharmacy, University of Birmingham, where I gained invaluable experience in curriculum design and delivery. I briefly returned to the lab in early 2018 to investigate the phenotype of osteoblasts from different regions of the spinal curve in scoliosis patients before moving to Aston University in March 2018 where I am currently a Teaching Fellow in Aston Medical School.

  • BSc (Hons) Biochemistry, Newcastle University, 2004
  • PhD, Newcastle University, 2008
  • 2009-2018, Post-Doctoral Research Fellow, University of Birmingham
  • 2017, Teaching Fellow, University of Birmingham
  • Musculoskeletal disease (osteoarthritis, rheumatoid arthritis, scoliosis)
  • Long Non-Coding (Lnc)RNAs
  • Inflammation
  • Biocompatability of biomaterials

Presentations

  • Invited speaker, CIMA/CMAR MRC-ARUK Epigenetics Meeting, University of Newcastle-upon-Tyne, UK, “LincRNAs mediate the inflammatory response in human OA synovium”, October 2016
  • Invited speaker, Exiqon miRNA and Non-Coding RNA Seminar, University of Birmingham, UK, “LncRNAs mediate the human OA inflammatory response”, October 2016
  • Invited speaker, Prof John Hesketh Research Symposium, University of Newcastle-upon-Tyne, UK, “LincRNAs mediate the inflammatory response in human OA joint tissues”, September 2016
  • Invited speaker: Inaugural OARSI Workshop on Epigenetics and OA, Amsterdam, NL, “LincRNAs mediate the human chondrocyte inflammatory response and are differentially expressed in cartilage from patients with osteoarthritis”, October 2015
  • Flash presentation, Biochemical Society Metabolic Drivers of Immunity, Aston University, “Obesity and osteoarthritis: joined at the hip by interleukin 17”, April 2015
  • Invited speaker, European Orthopaedic Research Society (EORS) Congress, Nantes, France, “Characterisation of CoCrMo wear debris from prosthetic hip implants and their interactions with the immune system”, July 2014
  • Invited speaker, Bio-Plex Multiplex Immunoassays User Meeting (Bio-Rad), Liverpool, UK, “Profiling inflammatory cytokines to determine the suitability of joint replacement implants”, December 2013
  • Invited speaker, Bio-Plex Multiplex Immunoassays User Meeting (Bio-Rad), London, UK, “Obesity and OA: Joined at the hip by inflammatory cytokines”, June 2013
  • Flash presentation, ARUK Research Symposium, Loughborough, “Obesity and OA: Joined at the hip by inflammatory cytokines”, May 2012

 

Poster Abstracts

  • OARSI World Congress, Amsterdam, NL, “Characterisation of the Biochemical and Biophysical Properties of Biomimetic Cartilage Models”, April 2016
  • OARSI World Congress, Amsterdam, NL, “LincRNAs mediate the inflammatory response in human OA joint tissues”, April 2016
  • Biochemical Society Metabolic Drivers of Immunity, Aston University, “The identification of differentially expressed long non-coding RNAs (lncRNAs) in obese patients with knee osteoarthritis that are induced by pro-inflammatory adipose-secreted cytokines”
  • European Orthopaedic Research Society (EORS) Congress, Nantes, France, Winner of best poster prize “The identification of differentially expressed long intergenic non-coding RNAs (lincRNAs) in knee osteoarthritis cartilage”, July 2014
  • Invited speaker, Bio-Plex Multiplex Immunoassays User Meeting (Bio-Rad), Liverpool, UK, “Profiling inflammatory cytokines to determine the suitability of joint replacement implants”, December 2013
  • International Cytokines Society: IL-17 and related cytokines, Trinity College, Dublin, Ireland, “Obesity and OA: Joined at the hip by IL-17”, July 2012
  • 20th European Society for Animal Cell Technology (ESACT), Dresden, Germany,  “Seamless cloning for the manipulation of the 3’UTR of mammalian expression vectors leads to enhanced recombinant protein expression”, June 2007

 

Conference Judge

  • Abstract reviewer and poster judge at the 9th Annual Saudi Student Conference, ICC, Birmingham, UK (Host University: University of Birmingham).

Pearson, M. J., Bik, M. A., Ospelt, C., Naylor, A., Wehmeyer, C., Jones, S. W., . . . Lord, J. M. (2018). Endogenous Galectin-9 suppresses apoptosis in human rheumatoid arthritis synovial fibroblasts. Sci Rep. (In Press)

Pearson, M. J., Herndler-Brandstetter, D., Tariq, M. A., Nicholson, T. A., Philp, A. M., Smith, H. L., . . . Lord, J. M. (2017). IL-6 secretion in osteoarthritis patients is mediated by chondrocyte-synovial fibroblast cross-talk and is enhanced by obesity. Sci Rep, 7(1), 3451. doi:10.1038/s41598-017-03759-w

Pearson, M. J., Grover, L. M., Lord, J. M., Jones, S. W., & Davis, E. T. (2017). Bearings in Hip Arthroplasty: Joint Registries vs Precision Medicine: Review Article. HSS J, 13(1), 20-27. doi:10.1007/s11420-016-9531-7

Cooke, M. E., Pearson, M. J., Moakes, R. J. A., Weston, C. J., Davis, E. T., Jones, S. W., & Grover, L. M. (2017). Geometric confinement is required for recovery and maintenance of chondrocyte phenotype in alginate. APL Bioengineering, 1(1), 016104. doi:10.1063/1.5006752

Pearson, M. J., Philp, A. M., Heward, J. A., Roux, B. T., Walsh, D. A., Davis, E. T., . . . Jones, S. W. (2016). Long Intergenic Noncoding RNAs Mediate the Human Chondrocyte Inflammatory Response and Are Differentially Expressed in Osteoarthritis Cartilage. Arthritis Rheumatol, 68(4), 845-856. doi:10.1002/art.39520

Pearson, M. J., & Jones, S. W. (2016). Review: Long Noncoding RNAs in the Regulation of Inflammatory Pathways in Rheumatoid Arthritis and Osteoarthritis. Arthritis Rheumatol, 68(11), 2575-2583. doi:10.1002/art.39759

Hardy, R. S., Doig, C. L., Hussain, Z., O'Leary, M., Morgan, S. A., Pearson, M. J., . . . Raza, K. (2016). 11beta-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation. J Pathol, 240(4), 472-483. doi:10.1002/path.4806

Spengler, J., Lugonja, B., Ytterberg, A. J., Zubarev, R. A., Creese, A. J., Pearson, M. J., . . . Scheel-Toellner, D. (2015). Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid. Arthritis Rheumatol, 67(12), 3135-3145. doi:10.1002/art.39313

Pearson, M. J., Williams, R. L., Floyd, H., Bodansky, D., Grover, L. M., Davis, E. T., & Lord, J. M. (2015). The effects of cobalt-chromium-molybdenum wear debris in vitro on serum cytokine profiles and T cell repertoire. Biomaterials, 67, 232-239. doi:10.1016/j.biomaterials.2015.07.034

Filer, A., Antczak, P., Parsonage, G. N., Legault, H. M., O'Toole, M., Pearson, M. J., . . . Falciani, F. (2015). Stromal transcriptional profiles reveal hierarchies of anatomical site, serum response and disease and identify disease specific pathways. PLoS ONE, 10(3), e0120917. doi:10.1371/journal.pone.0120917

Tonge, D. P., Pearson, M. J., & Jones, S. W. (2014). The hallmarks of osteoarthritis and the potential to develop personalised disease-modifying pharmacological therapeutics. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, 22(5), 609-621. doi:10.1016/j.joca.2014.03.004

Khaziapoul, S., Pearson, M. J., Pryme, I. F., Stern, B., & Hesketh, J. E. (2012). CUG binding protein 1 binds to a specific region within the human albumin 3' untranslated region. Biochem Biophys Res Commun, 426(4), 539-543. doi:10.1016/j.bbrc.2012.08.123

Pearson, M. J., Khazaipoul, S., Optun, A., Pryme, I. F., Stern, B., & Hesketh, J. E. (2012). Albumin 3'untranslated region facilitates increased recombinant protein production from Chinese hamster ovary cells. Biotechnol J, 7(11), 1405-1411. doi:10.1002/biot.201200044