Professor Yuchun Gu is a medically trained physiologist and is current the director of the Regenerative Medicine Centre of Aston Medical School. In 2017, he was awarded a professor and chair in Molecular Physiology at Aston Medical School and has held the positions of Professor and Chair of Molecular Pharmacology at the Institute of Molecular Medicine, Peking University since 2010. Professor Gu’s expertise lies in cardiovascular disease, mitochondria biology and ion channel studies. His research made a significant contribution in understanding of the role of CO in human physiological and path-physiological process. His discoveries identified three novel signal pathways mediated by CO. CO activates ENAC channels to promote water and salt reabsorption in renal tubules cells and fluid clearance in the lung. CO inhibits inward rectified potassium channels, which maintain the resting membrane potential in ventricle, neuron and excitable cells. CO could prevent ventricular arrhythmia after cardiac infarction. Additionally, CO activates PLCδ but not PLCβ. It therefore results in insulin release from diabetic animal or patients, but not health individuals. It reveals the great potential to apply CO clinically in treatment of diabetes. Moreover, recent discovery in his laboratory found that insulin sensitive glucose transporter 4 was under control by PIP2 and CFTR receptors. In the past 6 years, his research also moved into the field of immune cell engineering in challenging the prostate cancer and the clinic application of stem cell for a variety of degenerative diseases.
Zhang H, Wang Q, Gu J, Yin L, Liang S, Wu L, Xu H, Zhao C, Gu Y. (2018) Elevated mitochondrial SLC25A29 in cancer modulates metabolic status by increasing mitochondria-derived nitric oxide. Oncogene. 37(19):2545-2558.
Gu J, Zhang H, Ji B, Jiang H, Zhao T, Jiang R, Zhang Z, Tan S, Ahmed A, Gu Y. (2017) Vesicle miR-195 derived from Endothelial Cells Inhibits Expression of Serotonin Transporter in Vessel Smooth Muscle Cells. Sci Rep. 7:43546.
Cai M, Wang K, Murdoch CE, Gu Y, Ahmed A.（2017）Heterodimersation between VEGFR-1 and VEGFR2 and not the homodimers of VEGFR-1 inhibit VEGFR-2 activity. Vascular Pharmacology 88:11-20.
Wang Q, Zhang H, Xu H, Guo D, Shi H, Li Y, Zhang W, Gu Y. (2016) 5-HTR3 and 5-HTR4 located on the mitochondrial membrane and functionally regulated mitochondrial functions. Sci Rep 6:37336.
Xu H, Zhao M, Liang S, Huang Q, Xiao Y, Ye L, Wang Q, He L, Ma L, Zhang H, Zhang L, Jiang H, Ke X, Gu Y. (2016) The Effects of Puerarin on Rat Ventricular Myocytes and the Potential Mechanism. Sci Rep 6:35475.
Chen L, Zhang G, Khan AA, Guo X, Gu Y. (2016) Clinical Efficacy and Meta-Analysis of Stem Cell Therapies for Patients with Brain Ischemia. Stem Cells Int. 2016: 6129579.
Chen L, Zhang G, Gu Y, Guo X. (2016) Meta-Analysis and Systematic Review of Neural Stem Cells therapy for experimental ischemia stroke in preclinical studies. Sci Rep. 6:32291.
Guo D, Gu J, Jiang H, Ahmed A, Zhang Z, Gu Y. (2016) Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to the development of pulmonary arterial hypertension. J Mol Cell Cardiol. 91:179-87.
Guo D, Liang S, Wang S, Tang C, Yao B, Wan W, Zhang H, Jiang H, Ahmed A, Zhang Z, Gu Y. (2016) Role of epithelial Na+ channels in endothelial function. J Cell Sci. 129:290-7
Wang D, Wang Q, Yan G, Qiao Y, Sun L, Zhu B, Tang C, Gu Y. (2015) High glucose and interleukin 1β-induced apoptosis in human umbilical vein endothelial cells involves in down-regulation of monocarboxylate transporter 4. Biochem Biophys Res Commun. 466:607-14.
Guo DQ, Zhang H, Tan SJ, Gu YC. （2014）Nifedipine promotes the proliferation and migration of breast cancer cells. PLoS One. 9:e113649.
Liang S, Wang Q, Zhang W, Zhang H, Tan S, Ahmed A, Gu Y. (2014) Carbon monoxide inhibits inward rectifier potassium channels in cardiomyocytes. Nature Commun. 5:4676. doi: 10.1038/ncomms5676.
Yan J, Chen R, Liu P, Gu Y. (2014) Docosahexaenoic acid attenuates hypoxic pulmonary vasoconstriction by activating the large conductance Ca2+-activated K+ currents in pulmonary artery smooth muscle cells. Pulm Pharmacol Ther. 28:9-16.
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