BSC, PhD, AMIChemE, FHEA
Orcid ID: orcid.org/0000-0002-2427-4052
Tel: +44 (0) 121 204 3161 Email: email@example.com Room: MB438F
School of Life & Health Sciences Aston University Aston Triangle, B4 7ET
Imagine you are a Senior Scientist that was asked to develop a process for manufacturing Stem Cells to be used as Cell Therapies to target a wide range of diseases. Where would you start?
My whole carrier to date, I have been trained exactly for this scenario. In 2007, I have graduated with Honours as a Biochemical Engineer from Babes-Bolyai University in Cluj-Napoca, Romania. After working as a Chemical Engineer in Cluj-Napoca, Romania for 1.5 years, I have decided that Chemical Engineering is not sufficiently challenging for me. As a result, in 2009, I have moved countries to start my PhD as part of the Doctoral Training Centre in Regenerative Medicine at Loughborough University, UK. During my PhD project, I have addressed one of the key challenges in the manufacturing of Stem Cells and that was focused on non-enzymatic and non-damaging cell harvesting at the end of the culture. During my PhD, I have designed and engineered a proof-of-concept temperature-responsive microcarrier to be used as cell attachment substrate at large scales in bioreactors. These microcarriers were cheap to produce and allowed for non-enzymatic cell harvest in situ by simply lowering the temperature from 37ºC (physiological temperature) to room temperature.
After developing a taste for Regenerative Medicine and Stem Cells, in 2014, I have started working on an even more challenging and exciting project funded by the BBSRC Bioprocessing Research Industry Club (BRIC) which is a closed member club with strong links to industry, having companies such as Pall Life Sciences, GSK, MedImmune, ReNeuron, Fujifilm Diosynth Biotechnologies and many others involved. This project focused on addressing the same challenge, but from a different perspective by developing and designing an alternative and cost-effective cell culture process based on a liquid/liquid two phase system, to be used at large scales in bioreactors. In this scenario, the cells attached to ‘temporary microcarriers’ and at the end of the process, cell harvest was achieved by disassembling the temporary microcarriers.
2019 – Fellow of the Higher Education of Academy, PGCert, Aston University, UK
My research interests cover:
PhD studentship (School of Life and Health Sciences, Aston University) £70,824 (2017-2020)
Advancing the production of clean beef towards commercialisation (The Good Food Institute Award) $210,088 (2019-2020)
Fellow of Higher Education Academy (FHEA)
Associate Member of IChemE (AMIChemE)
Committee member of Biochemical Engineering Subject Interest Group (BESIG) IChemE
BESIG IChemE Travel Bursary Secretary
Biotechnology Letters Journal – editorial board
Tissue and Cell Engineering Society (TCES) member
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