Helen R. Griffiths (Honorary)

Honorary Professor in Biomedical Sciences

School of Life and Health Sciences
Aston University
Birmingham
B4 7ET
UK

Research Group

Research Centre

Aston Research Centre for Healthy Ageing (ARCHA)

British Council South Africa Workshop Opportunity - Closing date 30th November 2016 - for further enquiries email here

Early career researchers from UK universities and biomedical research institutes are invited to apply for funding to participate in a workshop to be held January 29-February 2, 2017 in South Africa. The workshop is the first milestone in an effort funded by the British Council to tackle the problem of Obesity in Egypt, South Africa, and the U.K. through collaborative basic and clinical studies in the fields of obesity and exercise research. The workshop will focus on the role of mitochondria, including high resolution functional and morphological assessments of mitochondria in the context of exercise and obesity. The workshop is entitled “Enhancing mechanistic understanding of exercise and obesity: designing personalised intervention strategies” and aims at building a network of researchers and clinicians from the three countries to address the obesity challenge.

Newton Scholars hosted

Dr Alaa Refaat, Zewail City University, Egypt, 2015. Read Alaa's blog here

Dr Tram Phamthikim, Ho Chi Min City Centre for Biotechnology, Vietnam. 2016

Member of the Biology Teaching Programme

December 2016 Executive Dean, Faculty of Health & Medical Sciences, University of Surrey
2015- 2016 Pro-Vice-Chancellor International Relations, Aston University
2009-2014 Executive Dean, LHS
2005–date Professor in Biomedical Sciences, Aston University
1998-2005 Reader in Molecular Biosciences, Aston University
1991-98 Lecturer in Pathology (0.5 FTE), University of Leicester
1989-91 Lecturer in Clinical Chemistry, University of Birmingham
1986-89 PhD, University of Birmingham
1985-86 Research Associate, Dept Immunology, University of Birmingham
1981-85 BSc. Hons, Biochemistry (Class I), University of Bath

Glenn Award for Ageing Research. 2014. Fellow of the Society of Biology. 2011. Aston Excellence Award for Outstanding Researcher of the Year 2009. 1st Catherine Pasquier Prize. From European Society for Free Radical Research 2004.

Chair, VNUK ASEAN hub steering committee 2015-

Vietnam UK Friendship Committee 2015-

Chair, British Society for Research on Ageing 2013- 2016

Chair, UK Deans of Science 2013-2015

European Society for Free Radical Research. 2008-2016

Biochemical Society Theme Panel III 2007-2016

BBRSC panel D member

Nutrient-gene interaction - effects on cellular and plasma omics

Interplay between lipids/sphingolipids and reactive oxygen species
Immune cell dysfunction during inflammation and ageing
Monocyte-endothelial cell dysfunction during inflammation
Intracellular redox regulation of cell survival and adaptation
Reversible protein oxidation during signalling, and the effects of irreversible modification on function

Financial support from Alzheimer’s Research UK (ARUK), BBSRC, ERDF, Marie Curie, Horizon 2020, British Council, KRUK and Industry is gratefully acknowledged.

Boost your career! Get funded for a world class research/training/transfer of knowledge experience at Aston University, Birmingham. Apply for a Marie Skłodowska-Curie Individual Fellowships. See HERE for details of current calls:

European Society for Free Radical Research

Biochemical Society

Nutrition Society

British Society for Research on Ageing

Recent Publications

Dias, HK, Griffiths, HR, Shabir, K, Brown, CLR & Polidori, MC 2018, 'miRNA 933 Expression by Endothelial Cells is Increased by 27-Hydroxycholesterol and is More Prevalent in Plasma from Dementia Patients' Journal of Alzheimer' s disease, pp. 1009-1017. DOI:10.3233/JAD-180201
Remtulla, AH , Dias, IH , Milic, I , Devitt, A & Griffiths, HR 2018, 'Protein sulphenic acid formation during CD4 + T cell activation' Free Radical Biology and Medicine, vol. 120, no. Suppl 1, pp. S120. DOI:10.1016/j.freeradbiomed.2018.04.396
Dias, HK , Milic, I, Lip, GYH, Polidori, MC, Devitt, A & Griffiths, HR 2018, 'Simvastatin reduces circulating oxysterol levels in men with hypercholesterolemia' Redox biology. DOI:10.1016/j.redox.2018.02.014
Rana, KS, Pararasa, C, Afzal, I , Nagel, DA , Hill, EJ , Bailey, CJ , Griffiths, HR , Kyrou, I, Randeva, HS, Bellary, S & Brown, JE 2017, 'Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels' Cardiovascular Diabetology, vol. 16, no. 1. DOI:10.1186/s12933-017-0627-2
Egea, J, Fabregat, I, Frapart, YM, Ghezzi, P, Görlach, A, Kietzmann, T, Kubaichuk, K, Knaus, UG, Lopez, MG, Olaso-Gonzalez, G, Petry, A, Schulz, R, Vina, J, Winyard, P, Abbas, K, Ademowo, OS , Afonso, CB, Andreadou, I, Antelmann, H, Antunes, F, Aslan, M, Bachschmid, MM, Barbosa, RM, Belousov, V, Berndt, C, Bernlohr, D, Bertrán, E, Bindoli, A, Bottari, SP, Brito, PM, Carrara, G, Casas, AI, Chatzi, A, Chondrogianni, N, Conrad, M, Cooke, MS, Costa, JG, Cuadrado, A, My-Chan Dang, P, De Smet, B, Debelec-Butuner, B, Dias, IHK, Dunn, JD, Edson, AJ, El Assar, M, El-Benna, J, Ferdinandy, P, Fernandes, AS, Fladmark, KE, Förstermann, U, Giniatullin, R, Giricz, Z, Görbe, A, Griffiths, H, Hampl, V, Hanf, A, Herget, J, Hernansanz-Agustín, P, Hillion, M, Huang, J, Ilikay, S, Jansen-Dürr, P, Jaquet, V, Joles, JA, Kalyanaraman, B, Kaminskyy, D, Karbaschi, M, Kleanthous, M, Klotz, LO, Korac, B, Korkmaz, KS, Koziel, R, Kracun, D, Krause, KH, Kren, V, Krieg, T, Laranjinha, J, Lazou, A, Li, H, Martínez-Ruiz, A, Matsui, R, McBean, GJ, Meredith, SP, Messens, J, Miguel, V, Mikhed, Y, Milisav, I, Milkovic, L, Miranda-Vizuete, A, Mojovic, M, Monsalve, M, Mouthuy, PA, Mulvey, J, Münzel, T, Muzykantov, V, Nguyen, ITN, Oelze, M, Oliveira, NG, Palmeira, CM, Papaevgeniou, N, Pavicevic, A, Pedre, B, Peyrot, F, Phylactides, M, Pircalabioru, GG, Pitt, AR, Poulsen, HE, Prieto, I, Rigobello, MP, Robledinos-Antón, N, Rodríguez-Mañas, L, Rolo, AP, Rousset, F, Ruskovska, T, Saraiva, N, Sasson, S, Schröder, K, Semen, K, Seredenina, T, Shakirzyanova, A, Smith, GL, Soldati, T, Sousa, BC , Spickett, CM, Stancic, A, Stasia, MJ, Steinbrenner, H, Stepanic, V, Steven, S, Tokatlidis, K, Tuncay, E, Turan, B, Ursini, F, Vacek, J, Vajnerova, O, Valentová, K, Van Breusegem, F, Varisli, L, Veal, EA, Yalçin, AS, Yelisyeyeva, O, Žarkovic, N, Zatloukalová, M, Zielonka, J, Touyz, RM, Papapetropoulos, A, Grune, T, Lamas, S, Schmidt, HHHW, Di Lisa, F & Daiber, A 2017, 'Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162]' Redox Biology, vol. In press. DOI:10.1016/j.redox.2017.10.001
Egea, J, Fabregat, I, Frapart, YM, Ghezzi, P, Görlach, A, Kietzmann, T, Kubaichuk, K, Knaus, UG, Lopez, MG, Olaso-Gonzalez, G, Petry, A, Schulz, R, Vina, J, Winyard, P, Abbas, K, Ademowo, S , Afonso, CB, Andreadou, I, Antelmann, H, Antunes, F, Aslan, M, Bachschmid, MM, Barbosa, RM, Belousov, V, Berndt, C, Bernlohr, D, Bertrán, E, Bindoli, A, Bottari, SP, Brito, PM, Carrara, G, Casas, AI, Chatzi, A, Chondrogianni, N, Conrad, M, Cooke, MS, Costa, JG, Cuadrado, A, My-Chan Dang, P, De Smet, B, Debelec–butuner, B, Dias, I, Dunn, JD, Edson, AJ, El Assar, M, El-Benna, J, Ferdinandy, P, Fernandes, AS, Fladmark, KE, Förstermann, U, Giniatullin, R, Giricz, Z, Görbe, A, Griffiths, H, Hampl, V, Hanf, A, Herget, J, Hernansanz-Agustín, P, Hillion, M, Huang, J, Ilikay, S, Jansen-Dürr, P, Jaquet, V, Joles, JA, Kalyanaraman, B, Kaminskyy, D, Karbaschi, M, Kleanthous, M, Klotz, L-O, Korac, B, Korkmaz, KS, Koziel, R, Kracun, D, Krause, K-H, Kren, V, Krieg, T, Laranjinha, J, Lazou, A, Li, H, Martínez-Ruiz, A, Matsui, R, Mcbean, GJ, Meredith, SP, Messens, J, Miguel, V, Mikhed, Y, Milisav, I, Milkovic, L, Miranda-Vizuete, A, Mojovic, M, Monsalve, M, Mouthuy, P-A, Mulvey, J, Münzel, T, Muzykantov, V, Nguyen, ITN, Oelze, M, Oliveira, NG, Palmeira, CM, Papaevgeniou, N, Pavicevic, A, Pedre, B, Peyrot, F, Phylactides, M, Pircalabioru, GG, Pitt, AR, Poulsen, HE, Prieto, I, Rigobello, MP, Robledinos-Antón, N, Rodríguez-mañas, L, Rolo, AP, Rousset, F, Ruskovska, T, Saraiva, N, Sasson, S, Schröder, K, Semen, K, Seredenina, T, Shakirzyanova, A, Smith, GL, Soldati, T, Sousa, BC , Spickett, CM, Stancic, A, Stasia, MJ, Steinbrenner, H, Stepanic, V, Steven, S, Tokatlidis, K, Tuncay, E, Turan, B, Ursini, F, Vacek, J, Vajnerova, O, Valentová, K, van Breusegem, F, Varisli, L, Veal, EA, Yalçin, AS, Yelisyeyeva, O, Žarkovic, N, Zatloukalová, M, Zielonka, J, Touyz, RM, Papapetropoulos, A, Grune, T, Lamas, S, Schmidt, HHHW, di Lisa, F & Daiber, A 2017, 'European contribution to the study of ROS: a summary of the findings and prospects for the future from the COST Action BM1203 (EU-ROS)' Redox biology, vol. 13, pp. 94-162. DOI:10.1016/j.redox.2017.05.007
Griffiths, HR, Gao, D & Pararasa, C 2017, 'Redox regulation in metabolic programming and inflammation' Redox biology, vol. 12, pp. 50-57. DOI:10.1016/j.redox.2017.01.023
Ademowo, OS , Dias, HKI , Milic, I , Devitt, A, Moran, R, Mulcahy, R, Howard, AN, Nolan, JM & Griffiths, HR 2017, 'Phospholipid oxidation and carotenoid supplementation in Alzheimer’s disease patients' Free Radical Biology and Medicine, vol. 108, pp. 77-85. DOI:10.1016/j.freeradbiomed.2017.03.008
Refaat, A, Pararasa, C, Arif, M, Brown, JEP, Carmichael, A, Ali, SS, Sakurai, H & Griffiths, HR 2017, 'Bardoxolone-methyl inhibits migration and metabolism in MCF7 cells' Free Radical Research, vol. 51, no. 2, pp. 211-221. DOI:10.1080/10715762.2017.1295452
Dias, IH , Milic, I , Devitt, A , Spickett, CM , Pitt, AR & Griffiths, HR 2016, 'Mass spectrometry based method for measurement of oxysterols' pp. S27. DOI:10.1016/j.freeradbiomed.2016.04.183
Meredith, SP, Parekh, G, Schouten, J, Wilkins, J, Griffiths, HR, Davis, P & Spickett, CM 2016, 'Generation of antibodies with varying sequence specifity for Oxidatively-modified peptides from human fibrinogen' pp. S28. DOI:10.1016/j.freeradbiomed.2016.04.185
Remtulla, A , Torrao, R, Wilmot, C & Griffiths, H 2016, 'The effect of oxidative stress on thioredoxin1 distribution and associated binding partners in T cells' pp. S40-S41. DOI:10.1016/j.freeradbiomed.2016.04.083
Refaat, A, Pararasa, C, Brown, J, Ali, A & Griffiths, H 2016, 'The Nrf2 activator methyl bardoxolone exacerbates mitochondrial dysfunction in palmitate-treated breast cancer cells' pp. S32-S33. DOI:10.1016/j.freeradbiomed.2016.04.065
Griffiths, H 2016, 'Biomarkers as tools to evaluate intervention in ageing' . DOI:10.1016/j.freeradbiomed.2016.04.040
Perrie, Y , Crofts, F , Devitt, A , Griffiths, HR, Kastner, E & Nadella, V 2016, 'Designing liposomal adjuvants for the next generation of vaccines' Advanced Drug Delivery Reviews, vol. 99, no. Part A, pp. 85-96. DOI:10.1016/j.addr.2015.11.005
Ikwuobe, J, Bellary, S & Griffiths, HR 2016, 'Innovative biomarkers for predicting type 2 diabetes mellitus: relevance to dietary management of frailty in older adults' Biogerontology, vol. First online. DOI:10.1007/s10522-016-9634-z
Pararasa, C, Ikwuobe, J, Shigdar, S, Boukouvalas, A, Nabney, IT , Brown, JE , Devitt, A , Bailey, CJ, Bennett, SJ & Griffiths, HR 2016, 'Age-associated changes in long-chain fatty acid profile during healthy aging promote pro-inflammatory monocyte polarization via PPAR?' Aging Cell, vol. 15, no. 1, pp. 128-139,10.1111/acel.12416
Pararasa, C, Ikwuobe, J, Shigdar, S, Boukouvalas, A, Nabney, IT , Brown, JE , Devitt, A , Bailey, CJ, Bennett, SJ & Griffiths, HR 2016, 'Age-associated changes in long-chain fatty acid profile during healthy aging promote pro-inflammatory monocyte polarization via PPAR?' Aging Cell, vol. 15, no. 1, pp. 128-139. DOI:10.1111/acel.12416
Russell, WR, Baka, A, Björck, I, Delzenne, N, Gao, D, Griffiths, HR, Hadjilucas, E, Juvonen, K, Lahtinen, S, Lansink, M, van Loon, L, Mykkänen, H, Riccardi, G, Östman, E, Vinoy, S & Weickert, MO 2016, 'Impact of diet composition on blood glucose regulation' Critical Reviews in Food Science and Nutrition, vol. 56, no. 4, pp. 541-590. DOI:10.1080/10408398.2013.792772
Dias, IHK, Brown, CLR, Polidori-Nelles, MC, Lip, GYH & Griffiths, HR 2015, 'LDL-Lipids from patients with hypercholesterolaemia and Alzheimer' s disease are inflammatory to microvascular endothelial cells: mitigation by statin intervention' Clinical Science, vol. 129, no. 12, pp. 1195-1206. DOI:10.1042/CS20150351
Bennett, SJ, Augustyniak, EM, Dunston, CR, Brown, RA, Shantsila, E, Lip, GYH, Torrão, RDC , Pararasa, C , Hussein, AR, Ladouce, R, Friguet, B & Griffiths, HR 2015, 'CD4⁺T cell surface alpha enolase is lower in older adults' Mechanisms of Ageing and Development, vol. 152, pp. 56–62. DOI:10.1016/j.mad.2015.09.005
Bürkle, A, Moreno-Villanueva, M, Bernhard, J, Blasco, M, Zondag, G, Hoeijmakers, JHJ, Toussaint, O, Grubeck-Loebenstein, B, Mocchegiani, E, Collino, S, Gonos, ES, Sikora, E, Gradinaru, D, Dollé, M, Salmon, M, Kristensen, P, Griffiths, HR, Libert, C, Grune, T, Breusing, N, Simm, A, Franceschi, C, Capri, M, Talbot, D, Caiafa, P, Friguet, B, Slagboom, PE, Hervonen, A, Hurme, M & Aspinall, R 2015, 'MARK-AGE biomarkers of ageing' Mechanisms of Ageing and Development, vol. 151, pp. 2-12. DOI:10.1016/j.mad.2015.03.006
Zong, G, Scott, A, Griffiths, H, Zock, P, Dietrich, T & Newson, R 2015, 'Serum a-tocopherol has a nonlinear inverse association with periodontitis among US adults' Free Radical Biology and Medicine, vol. 86, no. Suppl.1, PP67, pp. S41-S42. DOI:10.1016/j.freeradbiomed.2015.07.142
Dias, IHK , Ademowo, OS, Newey, E & Griffiths, HR 2015, 'The Nrf2-ARE activation protect neurones against oxidative stress' Free Radical Biology and Medicine, vol. 86, no. Suppl.1, PP34, pp. S30-S31. DOI:10.1016/j.freeradbiomed.2015.07.109
Meredith, S, Spickett, C, Parekh, G, Schouten, J, Griffiths, H & Davis, P 2015, 'Investigating the ability of antibodies to recognize specific oxidized protein epitopes' Free Radical Biology and Medicine, vol. 86, no. Suppl.1, PP36, pp. S31. DOI:10.1016/j.freebiomed.2015.07.0111
McBean, GJ, Aslan, M, Griffiths, HR & Torrão, RC 2015, 'Thiol redox homeostasis in neurodegenerative disease' Redox biology, vol. 5, pp. 186-194. DOI:10.1016/j.redox.2015.04.004
Zong , G, Scott, AE, Griffiths, HR, Zock , PL, Dietrich, T & Newson, RS 2015, 'Serum a-tocopherol has a nonlinear inverse association with periodontitis among US adults' Journal of Nutrition, vol. 145, no. 5, pp. 893-899. DOI:10.3945/jn.114.203703
Augustyniak, E, Adam, A, Wojdyla, K, Rogowska-Wrzesinska, A, Willetts, R, Korkmaz, A, Atalay, M, Weber, D, Grune, T, Borsa, C, Gradinaru, D, Chand Bollineni, R, Fedorova, M & Griffiths, H 2015, 'Validation of protein carbonyl measurement: a multi-centre study' Redox biology, vol. 4, pp. 149–157. DOI:10.1016/j.redox.2014.12.014
Perrie, Y , Griffiths, HR & Jones, D 2015, 'Enhancing vaccine design strategies: applications for protein science, proteomics and adjuvants' Journal of Pharmacy and Pharmacology, vol. 67, no. 3, pp. 287-289. DOI:10.1111/jphp.12414
Ruskovska, T, Bennett, SJ, Brown, CR, Dimitrov, S, Kamcev, N & Griffiths, HR 2015, 'Ankyrin is the major oxidised protein in erythrocyte membranes from end-stage renal disease patients on chronic haemodialysis and oxidation is decreased by dialysis and vitamin C supplementation' Free Radical Research, vol. 49, no. 2, pp. 175-185. DOI:10.3109/10715762.2014.991725
Pararasa, C , Bailey, CJ & Griffiths, HR 2015, 'Ageing, adipose tissue, fatty acids and inflammation' Biogerontology, vol. 16, no. 2, pp. 235-248. DOI:10.1007/s10522-014-9536-x
Marshall, LJ, Oguejiofor, W, Willetts, RS , Griffiths, HR & Devitt, A 2015, 'Developing accurate models of the human airways' Journal of Pharmacy and Pharmacology, vol. 67, no. 3, pp. 464-472. DOI:10.1111/jphp.12340
Taylor, S, Lam, M, Pararasa, C , Brown, JEP, Carmichael, AR & Griffiths, HR 2015, 'Evaluating the evidence for targeting FOXO3a in breast cancer: a systematic review' Cancer Cell International, vol. 15, no. 1. DOI:10.1186/s12935-015-0156-6
Dunston, CR, Herbert, R & Griffiths, HR 2015, 'Improving T cell-induced response to subunit vaccines: opportunities for a proteomic systems approach' Journal of Pharmacy and Pharmacology, vol. 67, no. 3, pp. 290-299. DOI:10.1111/jphp.12383
Griffiths, HR, Augustyniak, EM, Bennett, SJ, Debacq-Chainiaux, F, Dunston, CR, Kristensen, P, Melchjorsen, CJ, Navarrete, SA, Simm, A & Toussaint, O 2015, 'Novel ageing-biomarker discovery using data-intensive technologies' Mechanisms of Ageing and Development, vol. 151, pp. 114-121. DOI:10.1016/j.mad.2015.05.010
Griffiths, HR & Lip, GYH 2014, 'New biomarkers and risk stratification in atrial fibrillation: simplicity and practicality matter' Circulation, vol. 130, no. 21, pp. 1837-1839. DOI:10.1161/CIRCULATIONAHA.114.012870
Killick, JW, Bennett, SJ, Dias, IHK , Dunston, CR & Griffiths, HR 2014,A role for epigenetic modulation of the innate immune response during aging. in A Massoud & N Rezaei (eds),Immunology of aging.Springer, Berlin (DE), pp. 37-45. DOI:10.1007/978-3-642-39495-9_4
Griffiths, H , Dias, I, Lip, GYH, Spickett, C & Polidori, C 2014, 'Oxidised LDL lipids, statins and a blood-brain barrier' Free Radical Biology and Medicine, vol. 75, no. Suppl.1, OP2-3, pp. S15-S16. DOI:10.1016/j.freeradbiomed.2014.10.591
Meredith, S, Parekh, G, Towler, J, Schouten, J, Davis, P, Griffiths, H & Spickett, C 2014, 'Mapping nitro-tyrosine modifications in fibrinogen by mass spectrometry as a biomarker for inflammatory disease' Free Radical Biology and Medicine, vol. 75, no. Suppl.1, P87, pp. S50. DOI:10.1016/j.freeradbiomed.2014.10.819
Pararasa, C , Bailey, C & Griffiths, H 2014, 'Macrophage polarisation by fatty acids is PPARgamma-dependent' Free Radical Biology and Medicine, vol. 75, no. Suppl.1, P32, pp. S31-S32. DOI:10.1016/j.freeradbiomed.2014.10.764
Dias, IHK, Mistry, J, Fell, S, Reis, A, Spickett, CM, Polidori, MC, Lip, GYH & Griffiths, HR 2014, 'Oxidised LDL-lipids increase beta amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation' Free Radical Biology and Medicine, vol. 75, pp. 48–59. DOI:10.1016/j.freeradbiomed.2014.07.012
Rana, KS, Griffiths, HR , Brown, JE, Navas, P & Brown, J 2014, 'The interaction between metabolic disease and ageing' Global Journal of Obesity, Diabetes and Metabolic Syndrome, vol. 1, no. 1, 102.
Griffiths, HR, Bennett, SJ, Olofsson, P & Dunston, CR 2014, 'Thioredoxin as a putative biomarker and candidate target in age-related immune decline' Biochemical Society Transactions, vol. 42, no. 4, pp. 922-927. DOI:10.1042/BST20140162
Turner, JE, Bennett, SJ, Bosch, JA, Griffiths, HR & Aldred, S 2014, 'Ultra-endurance exercise: unanswered questions in redox biology and immunology' Biochemical Society Transactions, vol. 42, no. 4, pp. 989-895. DOI:10.1042/BST20140120
Dias, IHK, Polidori, MC & Griffiths, HR 2014, 'Hypercholesterolaemia-induced oxidative stress at the blood-brain barrier' Biochemical Society Transactions, vol. 42, no. 4, pp. 1001-1005. DOI:10.1042/BST20140164
Ghattas, A, Shantsila, E, Griffiths, H & Lip, G 2014, '36 monocyte subpopulations counts and associations with global longitudinal strain in st-elevation myocardial infarction patients with normal ejection fraction' Heart, vol. 100, no. Suppl.3, pp. A19-A20. DOI:10.1136/heartjnl-2014-306118.36
Torrão, RC, Bennett, SJ, Brown, JE & Griffiths, HR 2014, 'Does metabolic reprogramming underpin age-associated changes in T cell phenotype and function?' Free Radical Biology and Medicine, vol. 71, pp. 26–35. DOI:10.1016/j.freeradbiomed.2014.03.002
Choudhury, K, Clark , J & Griffiths, HR 2014, 'An almond-enriched diet increases plasma a-tocopherol and improves vascular function but does not affect oxidative stress markers or lipid levels' Free Radical Research, vol. 48, no. 5, pp. 599-606. DOI:10.3109/10715762.2014.896458
Dias, IHK & Griffiths, HR 2014, 'Oxidative stress in diabetes - circulating advanced glycation end products, lipid oxidation and vascular disease' Annals of Clinical Biochemistry, vol. 51, no. 2, pp. 125-127. DOI:10.1177/0004563213508747
Griffiths, HR , Dias, I , Willetts, RS & Devitt, A 2014, 'Redox regulation of protein damage in plasma' Redox biology, vol. 2, no. 1, pp. 430-435. DOI:10.1016/j.redox.2014.01.010
Dias, IHK, Polidori, MC, Li, L, Weber, D, Stahl, W, Nelles, G, Grune, T & Griffiths, HR 2014, 'Plasma levels of HDL and carotenoids are lower in dementia patients with vascular comorbidities' Journal of Alzheimer' s disease, vol. 40, no. 2, pp. 399-408. DOI:10.3233/JAD-131964
Rogowska-Wrzesinska, A, Wojdyla, K, Nedic, O, Baron, CP & Griffiths, HR 2014, 'Analysis of protein carbonylation - pitfalls and promise in commonly used methods' Free Radical Research, vol. 48, no. 10, pp. 1145-1162. DOI:10.3109/10715762.2014.944868
Ratnayake, S, Dias, IHK , Lattmann, E & Griffiths, HR 2013, 'Stabilising cysteinyl thiol oxidation and nitrosation for proteomic analysis' Journal of Proteomics, vol. 92, pp. 160-170. DOI:10.1016/j.jprot.2013.06.019
Ghattas, A, Griffiths, HR , Devitt, A, Lip, GYH & Shantsila, E 2013, 'Monocytes in coronary artery disease and atherosclerosis: where are we now?' Journal of the American College of Cardiology, vol. 62, no. 17, pp. 1541-1551. DOI:10.1016/j.jacc.2013.07.043
Turner, JE, Bennett, SJ, Campbell, JP, Bosch, JA, Aldred, S & Griffiths, HR 2013, 'The antioxidant enzyme peroxiredoxin-2 is depleted in lymphocytes seven days after ultra-endurance exercise' Free Radical Research, vol. 47, no. 10, pp. 821-828. DOI:10.3109/10715762.2013.828836
Bennett, SJ, Dunston, CR , Dias, IHK , Carilho, R, Augustyniak, E & Griffiths, HR 2013, 'Intracellular redox state modulates the T cell surface proteome – relevance to ageing' Free Radical Biology and Medicine, vol. 65, no. Suppl.1, pp. S11. DOI:10.1016/j.freeradbiomed.2013.08.129
Turner, JE, Bennett, SJ, Bosch, JA, Aldred, S & Griffiths, HR 2013, 'Lymphocyte peroxiredoxin-2 levels are depleted one week after ultra-endurance exercise' Free Radical Biology and Medicine, vol. 65, no. Suppl.1, PP90, pp. S56. DOI:10.1016/j.freeradbiomed.2013.08.099
Dias, HKI, Polidori, MC, Lip, GYH & Griffiths, HR 2013, 'Modified lipids from LDL in the blood during mid-life increase blood brain barrier permeability' Free Radical Biology and Medicine, vol. 65, no. Suppl.1, PP17, pp. S29. DOI:10.1016/j.freeradbiomed.2013.08.026
Zarkovic, N, Zarkovic, K, Milkovic, L, Andrisic, L, Borovic, S, Waeg, G, Weber, D, Bennett, SJ, Griffiths, HR & Gune, T 2013, 'Revealing 4-hydroxynonenal-histidine adducts as qualitative and quantitative biomarker of oxidative stress, lipid peroxidation and oxidative homeostasis' Free Radical Biology and Medicine, vol. 65, no. Suppl.1, pp. S14-S15. DOI:10.1016/j.freeradbiomed.2013.08.139
Carilho Torrão, RBD , Dias, IHK, Bennett, SJ, Dunston, CR & Griffiths, HR 2013, 'Healthy ageing and depletion of intracellular glutathione influences T cell membrane thioredoxin-1 levels and cytokine secretion' Chemistry Central Journal, vol. 7, no. 1, 150. DOI:10.1186/1752-153X-7-150
Ghattas, A, Shantsila, E, Griffiths, HR & Lip, GY 2013, 'Monocyte subset counts associations with left ventricular systolic function post ST elevation myocardial infarction' European Heart Journal, vol. 34, no. Suppl.1, 2837, pp. 513. DOI:10.1093/eurheartj/eht309.2837
Dias, IKI, Mistry, J, Tarzyluck, M, Hill, EJ, Bennett, SJ, Polidori, MC, Lip, GYH & Griffiths, HR 2013, 'Oxidised LDL-lipids alter redox ratio, lipid raft formation and increase amyloid beta production by SHSY-5Y cells' Experimental Gerontology, vol. 48, no. 7, pp. 688. DOI:10.1016/j.exger.2013.05.022
Dias, IHK, Chapple, ILC, Milward, M, Grant, MM, Hill, E , Brown, J & Griffiths, HR 2013, 'Sulforaphane restores cellular glutathione levels and reduces chronic periodontitis neutrophil hyperactivityin vitro' PLoS ONE, vol. 8, no. 6, e66407. DOI:10.1371/journal.pone.0066407
Ghattas, A, Shantsila, E, Devitt, A , Griffiths, H & Lip, GYL 2013, 'Monocyte subpopulation counts and TNF alpha associations with clinical outcome post ST elevation myocardial infarction' Heart, vol. 99, no. Suppl.2, 243, pp. A129-A130. DOI:10.1136/heartjnl-2013-304019.243
Ghattas, AG, Shantsila, ES, Griffiths, HRG & Lip, GYL 2013, 'Monocyte subpopulation counts and associations with left ventricular ejection fraction post ST elevation myocardial infarction' Heart, vol. 99, no. Suppl.2, 043, pp. A31. DOI:10.1136/heartjnl-2013-304019.43
Chapple, ILC, Matthews, JB, Wright, HJ, Scott, AE, Griffiths, HR & Grant, MM 2013, 'Ascorbate and a-tocopherol differentially modulate reactive oxygen species generation by neutrophils in response to Fc?R and TLR agonists' Innate Immunity, vol. 19, no. 2, pp. 152-159. DOI:10.1177/1753425912455207
Russell, W, Baka, A, Björck, I, Delzenne, N, Gao, D, Griffiths, H, Hadjilucas, E, Juvonen, K, Lahtinen, S, Lansink, M, van Loon, L, Mykkänen, H, Östman, E, Riccardi, G, Vinoy, S & Weickert, M 2013, 'Nutritional management of blood glucose levels' Annals of Nutrition and Metabolism, vol. 63, no. S1, PO2241, pp. 1339-1340. DOI:10.1159/000354245
Weber, D, Milkovic, L, Bennett, SJ, Griffiths, HR, Zarkovic, N & Grune, T 2013, 'Measurement of HNE-protein adducts in human plasma and serum by ELISA-Comparison of two primary antibodies' Redox biology, vol. 1, no. 1, pp. 226-233. DOI:10.1016/j.redox.2013.01.012
Kolamunne, RT, Dias, IHK , Vernallis, AB, Grant, MM & Griffiths, HR 2013, 'Nrf2 activation supports cell survival during hypoxia and hypoxia/reoxygenation in cardiomyoblasts; the roles of reactive oxygen and nitrogen species' Redox biology, vol. 1, no. 1, pp. 418-426. DOI:10.1016/j.redox.2013.08.002
Ghattas, A, Griffiths, HR, Lip, G & Shantsila, ES 2012, 'Functional characteristics of monocytes subsets in the acute and healing phases of ST Elevation Myocardial Infarction and their predictive role for major adverse cardiac events' Circulation, vol. 126, no. Suppl.21, A12560.
Ratnayake, S, Ratnayake, S, Dunston, C, Lattmann, E & Griffiths, H 2012, 'Novel agents for the in-situ detection of cysteine oxidation states' Free Radical Biology and Medicine, vol. 53, no. Supplement 2, 337, pp. S137-S138. DOI:10.1016/j.freeradbiomed.2012.10.375
Dunston, CR, Choudhury, K & Griffiths, HR 2012, 'Terminal galactose residues on transferrin are increased in mid-life adults compared to young adults' Proteomics, vol. 12, no. 21, pp. 3147-3153. DOI:10.1002/pmic.201100506
Dunston, CR, Bennett, SJ & Griffiths, HR 2012, 'Thioredoxin expression is reduced at the plasma membrane of CD4+ T-cells in mid-life adults compared to young adults' Free Radical Biology and Medicine, vol. 53, no. Supplement 1, 0570, pp. S82-S83. DOI:10.1016/j.freeradbiomed.2012.08.172
Pararasa, C , Gao, D , Dunston, CR , Bailey, CJ & Griffiths, HR 2012, 'Palmitate induces phenotype changes in monocytes via de novo ceramide synthesis' Free Radical Biology and Medicine, vol. 53, no. Supplement 1, 0501, pp. S136. DOI:10.1016/j.freeradbiomed.2012.08.284
Ghattas, A, Lip, GYH, Griffiths, HR & Shantsila, ES 2012, 'Predictive role of specific monocyte subsets for major adverse cardiac events after ST-elevation myocardial infarction' European Heart Journal, vol. 33, no. Suppl.1, P5095, pp. 919-920. DOI:10.1093/eurheartj/ehs283
Ghattas, A, Lip, GYH, Griffiths, HR & Shantsila, ES 2012, 'Functional characteristics of monocytes subsets in the acute and healing phases of ST elevation myocardial infarction and their effect on ejection fraction' European Heart Journal, vol. 33, no. Suppl.1, P4475, pp. 787. DOI:10.1093/eurheartj/ehs283
Gao, D, Pararasa, C, Dunston, CR , Bailey, CJ & Griffiths, HR 2012, 'Palmitate promotes monocyte atherogenicity via de novo ceramide synthesis' Free Radical Biology and Medicine, vol. 53, no. 4, pp. 796–806. DOI:10.1016/j.freeradbiomed.2012.05.026
Lam, M, Carmichael, A & Griffiths, H 2012, 'An aqueous extract of Fagonia cretica induces DNA damage, cell cycle arrest and apoptosis in breast cancer cells via FOXO3a and p53 expression' PLoS ONE, vol. 7, no. 6, e40152. DOI:10.1371/journal.pone.0102655
Ghattas, AA, Lip, GYH, Griffiths, H & Shantsila, E 2012, 'Monocyte subpopulation counts and functional characteristics predict adverse clinical events post ST elevation myocardial infarction' Heart, vol. 98, no. Suppl.1, 125, pp. A70-A71. DOI:10.1136/heartjnl-2012-301877b.125
Torr, EE, Gardner, DH, Thomas, L, Goodall, DM, Bielemeier, A, Willetts, R , Griffiths, HR , Marshall, LJ & Devitt, A 2012, 'Apoptotic cell-derived ICAM-3 promotes both macrophage chemoattraction to and tethering of apoptotic cells' Cell Death and Differentiation, vol. 19, no. 4, pp. 671-679. DOI:10.1038/cdd.2011.167
Wu, Z, Choudhury, K, Griffiths, HR, Xu, J & Ma, X 2012, 'A novel silicon membrane-based biosensing platform using distributive sensing strategy and artificial neural networks for feature analysis' Biomedical Microdevices, vol. 14, no. 1, pp. 83-93. DOI:10.1007/s10544-011-9587-6
Hawkins, L, Griffiths, H & Devitt, A 2012, 'Dealing with cell death – an ageing problem?' British Society for Research on Ageing, Birmingham, United Kingdom,2/07/12 -4/07/12 , pp. 59.
Griffiths, HR , Dunston, CR, Bennett, SJ, Grant, MM, Phillips, DC & Kitas, GD 2011, 'Free radicals and redox signalling in T-cells during chronic inflammation and ageing' Biochemical Society Transactions, vol. 39, no. 5, pp. 1273-1278. DOI:10.1042/BST0391273
Winyard, PG, Spickett, CM & Griffiths, HR 2011, 'Analysis of radicals and radical reaction products in cell signalling and biomolecular damage: the long hard road to gold-standard measures' Biochemical Society Transactions, vol. 39, no. 5, pp. 1217-1220. DOI:10.1042/BST0391217
Allen, EM, Matthews, JB, O' Halloran, DJ, Griffiths, HR & Chapple, IL 2011, 'Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis' Journal of Clinical Periodontology, vol. 38, no. 10, pp. 894-901. DOI:10.1111/j.1600-051X.2011.01764.x
Qin, L, Bartlett, HE , Griffiths, HR , Eperjesi, F , Armstrong, RA & Gherghel, D 2011, 'Macular pigment optical density is related to blood glutathione levels in healthy individuals' Investigative Ophthalmology and Visual Science, vol. 52, no. 9, pp. 5029-5033. DOI:10.1167/iovs.11-7240
McNeil, SE, Griffiths, HR & Perrie, Y 2011, 'Polycaprolactone fibres as a potential delivery system for collagen to support bone regeneration' Current Drug Delivery, vol. 8, no. 4, pp. 448-455.
Gonenc, A, HacIsevki, A, Griffiths, HR, Torun, M, Bakkaloglu, B & Simsek, B 2011, 'Free radical reaction products and antioxidant capacity in beating heart coronary artery surgery compared to conventional bypass' ????????/Biochemistry, vol. 76, no. 6, pp. 677-685. DOI:10.1134/S0006297911060083
Ma, X & Griffiths, H 2011,VIBRATING MICROPLATE BIOSENSING FOR CHARACTERISING PROPERTIES OF BEHAVIOUR BIOLOGICAL CELLS, Patent No. GB 1104462.5, IPC No. G01N29/02,G01N29/036,G01N33/487,G01N33/543.
Akbar, S, Bellary, S & Griffiths, HR 2011, 'Dietary antioxidant interventions in type 2 diabetes patients: a meta-analysis' British Journal of Diabetes and Vascular Disease, vol. 11, no. 2, pp. 62-68. DOI:10.1177/1474651411407558
Toms, TE, Panoulas, VF, Douglas, KMJ, Nightingale, P, Smith, JP, Griffiths, H, Sattar, N, Symmons, DPM & Kitas, GD 2011, 'Are lipid ratios less susceptible to change with systemic inflammation than individual lipid components in patients with rheumatoid arthritis?' Angiology, vol. 62, no. 2, pp. 167-175. DOI:10.1177/0003319710373749
Kolamunne, RT, Clare, M & Griffiths, HR 2011, 'Mitochondrial superoxide anion radicals mediate induction of apoptosis in cardiac myoblasts exposed to chronic hypoxia' Archives of Biochemistry and Biophysics, vol. 505, no. 2, pp. 256-265. DOI:10.1016/j.abb.2010.10.015
Dias, IHK, Matthews, JB, Chapple, ILC, Wright, HJ, Dunston, CR & Griffiths, HR 2011, 'Activation of the neutrophil respiratory burst by plasma from periodontitis patients is mediated by pro-inflammatory cytokines' Journal of Clinical Periodontology, vol. 38, no. 1, pp. 1-7. DOI:10.1111/j.1600-051X.2010.01628.x
Dunston, CR , Griffiths, HR , Lambert, PA, Staddon, S & Vernallis, AB 2011, 'Proteomic analysis of the anti-inflammatory action of minocycline' Proteomics, vol. 11, no. 1, pp. 42-51. DOI:10.1002/pmic.201000273
Hawkins, L, Griffiths, H & Devitt, A 2010, 'Modelling Apoptotic cell clearance within the atherosclerotic plaque' 2010 British Society for Immunology Annual Congress, Liverpool, United Kingdom,6/12/10 -10/12/10 , .
Grant, MM, Kolamunne, RT, Lock, FE, Matthews, JB, Chapple, ILC & Griffiths, HR 2010, 'Oxygen tension modulates the cytokine response of oral epithelium to periodontal bacteria' Journal of Clinical Periodontology, vol. 37, no. 12, pp. 1039-1048. DOI:10.1111/j.1600-051X.2010.01622.x
Pamukcu, B, Lip, GYH, Devitt, A , Griffiths, H & Shantsila, E 2010, 'The role of monocytes in atherosclerotic coronary artery disease' Annals of Internal Medicine, vol. 42, no. 6, pp. 394-403. DOI:10.3109/07853890.2010.497767
Dunston, C & Griffiths, HR 2010, 'The effect of ageing on macrophage Toll-like receptor-mediated responses in the fight against pathogens' Clinical and Experimental Immunology, vol. 161, no. 3, pp. 407-416. DOI:10.1111/j.1365-2249.2010.04213.x
Polidori, MC, Pientka, L, Nelles, G & Griffiths, HR 2010, 'Modulation of cholesterol in midlife affords cognitive advantage during ageing - a role for altered redox balance' International Journal of Clinical and Experimental Medicine, vol. 3, no. 2, pp. 103-109.
Grant, MM, Creese, AJ, Barr, G, Ling, MR, Scott, AE, Matthews, JB, Griffiths, HR, Cooper, HJ & Chapple, ILC 2010, 'Proteomic analysis of a noninvasive human model of acute inflammation and its resolution: the twenty-one day gingivitis model' Journal of Proteome Research, vol. 9, no. 9, pp. 4732-4744. DOI:10.1021/pr100446f
Toms, TE, Panoulas, VF, Douglas, KMJ, Griffiths, H, Sattar, N, Smith, JP, Symmons, DPM, Nightingale, P, Metsios, GS & Kitas, GD 2010, 'Statin use in rheumatoid arthritis in relation to actual cardiovascular risk: evidence for substantial undertreatment of lipid-associated cardiovascular risk?' Annals of the Rheumatic Diseases, vol. 69, no. 4, pp. 683-688. DOI:10.1136/ard.2009.115717
Li, L, Willetts, R, Polidori, MC, Stahl, W, Nelles, G, Sies, H & Griffiths, HR 2010, 'Oxidative LDL modification is increased in vascular dementia and is inversely associated with cognitive performance' Free Radical Research, vol. 44, no. 3, pp. 241-248. DOI:10.3109/10715760903440153
Phillips, DC, Dias, HKI, Kitas, GD & Griffiths, HR 2010, 'Aberrant reactive oxygen and nitrogen species generation in rheumatoid arthritis (RA): causes and consequences for immune function, cell survival, and therapeutic intervention' Antioxidants and Redox Signaling, vol. 12, no. 6, pp. 743-85. DOI:10.1089/ars.2009.2607
Gao, D , Bailey, CJ & Griffiths, HR 2009, 'Metabolic memory effect of the saturated fatty acid, palmitate, in monocytes' Biochemical and Biophysical Research Communications, vol. 388, no. 2, pp. 278-282. DOI:10.1016/j.bbrc.2009.07.160
Gao, D , Griffiths, HR & Bailey, CJ 2009, 'Oleate protects against palmitate-induced insulin resistance in L6 myotubes' British Journal of Nutrition, vol. 102, no. 11, pp. 1557-1563. DOI:10.1017/S0007114509990948
Ma, X, Wu, Z, Brett, P, Wright, M & Griffiths, H 2009,Characterising properties or behavior of biological cells, Patent No. GB 0911331.7, IPC No. G01N27/00.
Griffiths, HR, Willetts, RS, Grant, MM, Mistry, N, Lunec, J & Bevan, RJ 2009, 'In vivo vitamin C supplementation increases phosphoinositol transfer protein expression in peripheral blood mononuclear cells from healthy individuals' British Journal of Nutrition, vol. 101, no. 10, pp. 1432-1439. DOI:10.1017/S0007114508079646
Toms, TE, Panoulas, VF, Douglas, KMJ, Griffiths, HR & Kitas, GD 2008, 'Lack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study' Arthritis Research and Therapy, vol. 10, no. 6, R145. DOI:10.1186/ar2578
Griffiths, HR 2008, 'Is the generation of neo-antigenic determinants by free radicals central to the development of autoimmune rheumatoid disease?' Autoimmunity Reviews, vol. 7, no. 7, pp. 544-549. DOI:10.1016/j.autrev.2008.04.013
Dias, IHK , Marshall, L , Lambert, PA, Chapple, ILC, Matthews, JB & Griffiths, HR 2008, 'Gingipains from Porphyromonas gingivalis increase the chemotactic and respiratory burst-priming properties of the 77-amino-acid interleukin-8 variant' Infection and Immunity, vol. 76, no. 1, pp. 317-323. DOI:10.1128/IAI.00618-07
Coleman, MD, Zilz, TR, Griffiths, HR & Woehrling, EK 2008, 'A comparison of the apoptotic and cytotoxic effects of hexanedione derivatives on human non-neuronal lines and the neuroblastoma line SH-SY5Y' Basic and Clinical Pharmacology and Toxicology, vol. 102, no. 1, pp. 25-29. DOI:10.1111/j.1742-7843.2007.00148.x
Griffiths, HR, Grune, T, Gonos, E & Kartal-Ozer, N 2008, 'Report of Society for Free Radical Research Europe Summer School' Biofactors, vol. 33, no. 2, pp. 157-160. DOI:10.1002/biof.5520330208

Helen R. Griffiths (Honorary)

Honorary Professor in Biomedical Sciences

Research Centre

British Council South Africa Workshop Opportunity - Closing date 30th November 2016 - for further enquiries email here

Newton Scholars hosted

Teaching activity

Career history

Prizes

Committee memberships

Research interests

Research funding

Marie Skłodowska-Curie Individual Fellowships.

Society memberships

Recent Publications