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LHS staff staff within the school of life and health sciences

Dr Eric Lattmann

Lecturer in Medicinal Chemistry

Member of the Pharmacy and Biology Teaching Programmes

School of Life & Health Sciences

Aston University
Aston Triangle
Birmingham
B4 7ET
UK

email: e.lattmann@aston.ac.uk
telephone: +44 (0) 121 204 3980

Research Group

Cell & Tissue Biomedical Research

Research Centre

Aston Research Centre for Healthy Ageing (ARCHA)

Teaching Activity on the MPharm Programme
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PH1405, PH3605, PH4701

Career History
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1997-date Lecturer in Medicinal Chemistry, Aston University
1995-96 Research Fellow, University of Aberdeen
1993-95 PhD, Organic Chemistry (summa cum laude), University of Hannover
1988-92 MSc, Chemistry, University of Hannover

Research Interests
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Design and synthesis of new drugs from combinatorial libraries and natural products

Combinatorial synthesis and automated synthesis
Chemistry and biology of Cholecystokinin antagonists
Synthesis and evaluation of Kawa lactones and Hyperforin based anti-depressants
Snake bite antidotes
Novel analgesic drugs

Recent Publications

Lattmann, E, Sattayasai, J, Narayanan, R, Benyamen, J, Balaram, PN & Lattmann, P 2018, 'CCK2–Gastrin Antagonist: Development of PNB-001 (4-Chloro- 5-Hydroxy-1-Phenylethyl-5-Phenyl-1, 5-Dihydro-Pyrrol-2-one) as Anti-Inflammatory Analgesic' SAJ Pharmacy and Pharmacology, vol. 2, no. 1, 105.
Lattmann, E, Sattayasai, J, Narayanan, R, Ngoc, N, Burrell, D, Balaram, PN, Palizdar, T & Lattmann, P 2017, 'Cholecystokinin-2/gastrin antagonists: 5-hydroxy-5-aryl-pyrrol-2-ones as anti-inflammatory analgesics for the treatment of inflammatory bowel disease' MedChemComm, vol. 8, no. 3, pp. 680-685. DOI:10.1039/c6md00707d
Lattmann, E, Russell, ST, Schwalbe, CH, Shortt, A, Balaram, PN, Theochari, E, Alharbi, M, Narayanan, R & Lattmann, P 2016, 'Cholecystokinin-1 receptor antagonists: 5-hydroxy-5-aryl-pyrrol-2-ones as anticancer agents' MedChemComm, vol. 7, no. 6, pp. 1138-1145. DOI:10.1039/c6md00052e
Lattmann, E, Sattayasai, J, Schwalbe, CH, Boonprakob, Y, Dunn, S, Fajana, F & Lattmann, P 2016, 'Analgesic effects of 5-alkyloxy-4-amino-2(5H)-furanones as cholecystokinin-2 antagonists' Archiv der Pharmazie, vol. 349, no. 6, pp. 456-465. DOI:10.1002/ardp.201600036
Ponnusamy, S, Lattmann, E, Lattmann, P, Thiyagarajan, T, Padinjarethalakal, BN & Narayanan, R 2016, 'Novel, isoform-selective, cholecystokinin A receptor antagonist inhibits colon and pancreatic cancers in preclinical models through novel mechanism of action' Oncology Reports, vol. 35, no. 4, pp. 2097-2106. DOI:10.3892/or.2016.4588
Chaithongyot, S, Asgar, A, Senawong, G, Yowapuy, A, Lattmann, E, Sattayasai, N & Senawong, T 2015, 'Anticancer effects of Curcuma C20-dialdehyde against colon and cervical cancer cell lines' Asian Pacific Journal of Cancer Prevention, vol. 16, no. 15, pp. 6513-6519. DOI:10.7314/APJCP.2015.16.15.6513
Ratnayake, S, Dias, IHK , Lattmann, E & Griffiths, HR 2013, 'Stabilising cysteinyl thiol oxidation and nitrosation for proteomic analysis' Journal of Proteomics, vol. 92, pp. 160-170. DOI:10.1016/j.jprot.2013.06.019
Ratnayake, S, Ratnayake, S, Dunston, C, Lattmann, E & Griffiths, H 2012, 'Novel agents for the in-situ detection of cysteine oxidation states' Free Radical Biology and Medicine, vol. 53, no. Supplement 2, 337, pp. S137-S138. DOI:10.1016/j.freeradbiomed.2012.10.375
Sattayasai, J, Bantadkit, J, Aromdee, C, Lattmann, E & Airarat, W 2012, 'Antipyretic, analgesic and anti-oxidative activities ofAquilaria crassnaleaves extract in rodents' Journal of Ayurveda and Integrative Medicine, vol. 3, no. 4, pp. 175-179. DOI:10.4103/0975-9476.104427
Bibi, S, Lattmann, E , Mohammed, A-U-R & Perrie, Y 2012, 'Trigger release liposome systems: local and remote controlled delivery?' Journal of Microencapsulation, vol. 29, no. 3, pp. 262-276. DOI:10.3109/02652048.2011.646330
Salama, R, Sattayasai, J, Gande, AK, Sattayasai, N, Davis, M & Lattmann, E 2012, 'Identification and evaluation of agents isolated from traditionally used herbs againstOphiophagus hannahvenom' Drug Discoveries and Therapeutics, vol. 6, no. 1, pp. 18-23. DOI:10.5582/ddt.2012.v6.1.18
Bibi, S, Kaur, R, Henriksen-Lacey, M, McNeil, SE, Wilkhu, J, Lattmann, E, Christensen, D, Mohammed, A-U-R & Perrie, Y 2011, 'Microscopy imaging of liposomes: from coverslips to environmental SEM' International Journal of Pharmaceutics, vol. 417, no. 1-2, pp. 138-150. DOI:10.1016/j.ijpharm.2010.12.021
Singh, H, Sattayasai, J, Lattmann, P, Boonprakob, Y & Lattmann, E 2010, 'Antidepressant/anxiolytic and anti-nociceptive effects of novel 2-substituted 1,4-benzodiazepine-2-ones' Scientia Pharmaceutica, vol. 78, no. 2, pp. 155-169. DOI:10.3797/scipharm.1004-12
Lattmann, E, Sattayasai, J, Sattayasai, N, Staaf, A, Phimmasone, S, Schwalbe, CH & Chaveerach, A 2010, 'In-vitro and in-vivo antivenin activity of 2-[2-(5,5,8a-trimethyl-2- methylene-decahydro-naphthalen-1-yl)-ethylidene]-succinaldehyde againstOphiophagus hannahvenom' Journal of Pharmacy and Pharmacology, vol. 62, no. 2, pp. 257-262. DOI:10.1211/jpp.62.02.0014

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