Senior Lecturer on the Undergraduate Pharmacy Programme
Email: email@example.com Telephone: +44 (0) 121 204 4049 Fax: +44 (0) 121 359 0733
Aston Research Centre for Healthy Ageing (ARCHA)
PH1401 (Module coordinator): NNeuronal excitability, cardiovascular physiology, endocrinology, brain anatomy, respiration and blood pressure practical classes.
PH2509: Anaemia, haemostasis, inotropy, vasodilators
PH3601: Dementia, affective disorders, Stroke.
PHM016-PHM025: Cardiovascular, Calcium signaling
Pharmacy Programme First year Tutor
In recent years it has become clear that in addition to their traditional roles as “housekeepers” of the brain’s environment, astrocytes can also signal to neurones using many of the mechanisms previously thought exclusive to neuronal transmission. The release of such transmitters as glutamate and ATP can elicit and affect neuronal excitability and modulate synaptic transmission.
The focus of my research is on the mechanisms of astrocyte-neuron signalling in the thalamus, and how such signalling is involved in thalamic function. The techniques used are combined electrophysiological recording and Calcium imaging.
Movie 1. Monochrome movie of spontaneous astrocytic calcium elevations in a VB thalamus slice. Slices are loaded with Fluo-4AM, an dimaged using a Cairn Optoscan monochromator and Hamamatsu Orca ER camera operated with Compix Simple PCI software. Images taken every 5s.
Movie 2. Pseudocolour movie showing a patch clamped astrocyte in a VB thalamus slice filled with Fluo-4 and imaged with a Noran Odyssey confocal microscope. Stimulation of the sensory but not of the cortical afferents results in a [Ca2+]i elevation in a process located on the left side of the astrocytic soma, which then propagates to the soma and throughout the other visible astrocytic processes. Images were acquired at 1Hz.
Movie 3. VB thalamus slice loaded with 1mM SR101. Movie shows Z-series revealing astrocytic morphology and processes within the slice.
MESOBrain – EU funded consortium with Hanover, Barcelona, Cambridge. “Building Bespoke human cortical networks on 3D 2-PP scaffolds”.
EuGliaPhD – EU funded ITN with partners in Amsterdam, Bonn, Padova, Milan, Paris, Montpellier, Copenhagen. Homburg (coordinator).
Photon-build – EPSRC-DTC funded studentship
Current PhD Students
A closer look at neuron interaction with track-etched microporous membranes. George J., Hill EJ., Nagel DA., Parri HR., Coleman MD., Ye C. Nature Scientific Reports, 2018. 19 Oct 2018, In : Scientific Reports. 8, 1, 15552.
In vitro Models for Seizure-Liability Testing Using Induced Pluripotent Stem Cells.Grainger AI, King MC, Nagel DA, Parri HR, Coleman MD, Hill EJ. Frontiers in Neuroscience. 2018 Aug 31;12:590.
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