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Professor Yvonne Perrie

Life & Health Sciences

Position: Visiting Professor in Pharmaceutics/Drug Delivery, Previously Head of Pharmacy
Phone: 0121 204 3991
Email: y.perrie@aston.ac.uk

Research Group

Molecular Biomedical Research

Research Centre

Professor Yvonne Perrie

Yvonne Perrie's research team

Our research team

1995 - 98
PhD, The School of Pharmacy, University of London
(Supervisor, Prof. G. Gregoriadis)
1994 - 95
Pre-registration Pharmacist training, R.W. McConnell & Son, Scotland.
1990 - 94
BSc Hons, Pharmacy (1st Class), University of Strathclyde

Currently Chair in Drug Delivery within the University of Strathclyde
2007-16 Head of Pharmacy, Aston University
2005 - 07
Senior Lecturer in Pharmaceutics, Aston University

2000 - 05
Lecturer in Pharmaceutics, Aston University

1999 - 00
Pharmaceutical Scientist/Industrial Lecturer (joint position), Lipoxen Ltd., The School of Pharmacy, University of London.

1998 - 99
Research Fellow, The School of Pharmacy, University of London

Pharmaceutics and Drug Delivery across a range of programmes including the MPharm programme, OSPAP, MSc in Drug Delivery and MSc in Pharmaceutical Engineering.

Particulate drug delivery systems (including liposomes, niosomes and nanoparticles) offer a range of advantages for drug delivery, but their clinical application remains under exploited. My research generates a deeper understanding of formulation attributes that govern the mechanism of action of these particulate systems for drug delivery, vaccine adjuvanticity and diagnostics. This reinforces their development and the pathway of these systems into clinical trials and application. By continued systematic development of such systems, my research provides the foundation for practical solutions and realistic options to enhance patient care on a global scale.

My research group gratefully acknowledges the support of: EPSRC, EU 6th Framework programme, Lipoxen Technologies Ltd, Pfizer Global Research, Astisen Ltd, Wellcome, and The Royal Society.

Registrant with theGeneral Pharmaceutical Council
Eminent Fellow of theAcademy of Pharmaceutical Sciences
Fellow of theRoyal Pharmaceutical Society
Fellow of theSociety of Biology
Controlled Release Society
Global Pharmaceutical Sciences Education Network
UK and Ireland Controlled Release Society (UKICRS)

Recent Publications

Khadke, S, Stone, P , Rozhin, O, Kroonen, J & Perrie, Y 2017, 'Point of use production of liposomal solubilised products' International Journal of Pharmaceutics. DOI:10.1016/j.ijpharm.2017.12.012
Badhan, RKS, Khadke, S & Perrie, Y 2017, 'Application of pharmacokinetics modelling to predict human exposure of a cationic liposomal subunit antigen vaccine system' Pharmaceutics, vol. 9, no. 4, 57. DOI:10.3390/pharmaceutics9040057
Dimov, N, Kastner, E, Hussain, M , Perrie, Y & Szita, N 2017, 'Formation and purification of tailored liposomes for drug delivery using a module-based micro continuous-flow system' Scientific Reports, vol. 7, no. 1, 12045. DOI:10.1038/s41598-017-11533-1
Miriyala, N, Ouyang, D, Perrie, Y, Lowry, D & Kirby, DJ 2017, 'Activated carbon as a carrier for amorphous drug delivery: effect of drug characteristics and carrier wettability' European Journal of Pharmaceutics and Biopharmaceutics, vol. 115, pp. 197–205. DOI:10.1016/j.ejpb.2017.03.002
Joshi, S, Kirby, D, Perrie, Y & Singh, SR 2017,Novel nano-biomaterials for inhibition of respiratory syncytial virus. inBiotech, Biomaterials and Biomedical - TechConnect Briefs 2017.vol. 3, TechConnect, pp. 75-78, 11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo, and the 2017 National SBIR/STTR Conference, Washington, United States, 14-17 May.
Perrie, Y, Kastner, E, Khadke, S, Roces, CB & Stone, P 2016,Manufacturing methods for liposome adjuvants. in CB Fox (ed.),Vaccine adjuvants: methods and protocols.Methods in Molecular Biology, vol. 1494, Springer, New York (US), pp. 127-144. DOI:10.1007/978-1-4939-6445-1_9
Stokes, CA, Kaur, R, Edwards, MR, Mondhe, M, Robinson, D, Prestwich, EC, Hume, RD, Marshall, CA, Perrie, Y, O' Donnell, VB, Harwood, JL, Sabroe, I & Parker, LC 2016, 'Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes' Mucosal Immunology, vol. 9, no. 5, pp. 1303-1316. DOI:10.1038/mi.2015.137
Nguyen, DB, Thuy Ly, TB, Wesseling, MC, Hittinger, M, Torge, A, Devitt, A , Perrie, Y & Bernhardt, I 2016, 'Characterization of microvesicles released from human red blood cells' Cellular Physiology and Biochemistry, vol. 38, no. 3, pp. 1085-1099. DOI:10.1159/000443059
Perrie, Y , Crofts, F , Devitt, A , Griffiths, HR, Kastner, E & Nadella, V 2016, 'Designing liposomal adjuvants for the next generation of vaccines' Advanced Drug Delivery Reviews, vol. 99, no. Part A, pp. 85-96. DOI:10.1016/j.addr.2015.11.005
Koner, JS, Rajabi-Siahboomi, A, Bowen, J, Perrie, Y , Kirby, D & Mohammed, AR 2015, 'A holistic multi evidence approach to study the fragmentation behaviour of crystalline mannitol' Scientific Reports, vol. 5, 16352. DOI:10.1038/srep16352
Perrie, Y & Marshall, K 2015, 'Nothing wrong with the quality of MPharm graduates' Pharmaceutical Journal, vol. 295, no. 7876-7877, pp. 147. DOI:10.1211/PJ.2015.20069066
Kastner, E, Verma, V, Lowry, D & Perrie, Y 2015, 'Microfluidic-controlled manufacture of liposomes for the solubilisation of a poorly water soluble drug' International Journal of Pharmaceutics, vol. 485, no. 1-2, pp. 122-130. DOI:10.1016/j.ijpharm.2015.02.063
Al-Khattawi, A, Koner, J, Rue, P, Kirby, D , Perrie, Y, Rajabi-Siahboomi, A & Mohammed, AR 2015, 'A pragmatic approach for engineering porous mannitol and mechanistic evaluation of particle performance' European Journal of Pharmaceutics and Biopharmaceutics, vol. 94, pp. 1-10. DOI:10.1016/j.ejpb.2015.04.011
Perrie, Y , Griffiths, HR & Jones, D 2015, 'Enhancing vaccine design strategies: applications for protein science, proteomics and adjuvants' Journal of Pharmacy and Pharmacology, vol. 67, no. 3, pp. 287-289. DOI:10.1111/jphp.12414
Russell, C, Begum, S, Hussain, Y, Hussain, M, Huen, D, Rahman, AS, Perrie, Y & Mohammed, AR 2015, 'Paediatric drug development of ramipril: reformulation,in vitroandin vivoevaluation' Journal of Drug Targeting, vol. 23, no. 9, pp. 854-863. DOI:10.3109/1061186X.2015.1036275
Kastner, E, Hussain, MJ, Bramwell, VW, Christensen, D & Perrie, Y 2015, 'Correlating liposomal adjuvant characteristics to in-vivo cell-mediated immunity using a novelMycobacterium tuberculosisfusion protein: a multivariate analysis study' Journal of Pharmacy and Pharmacology, vol. 67, no. 3, pp. 450-463. DOI:10.1111/jphp.12390
Kastner, E, Kaur, R, Lowry, D, Moghaddam, B, Wilkinson, A & Perrie, Y 2014, 'High-throughput manufacturing of size-tuned liposomes by a new microfluidics method using enhanced statistical tools for characterization' International Journal of Pharmaceutics, vol. 477, no. 1-2, pp. 361-368. DOI:10.1016/j.ijpharm.2014.10.030
Wilkhu, JS, McNeil, SE, Anderson, DE & Perrie, Y 2014, 'Consideration of the efficacy of non-ionic vesicles in the targeted delivery of oral vaccines' Drug Delivery and Translational Research, vol. 4, no. 3, pp. 233-245. DOI:10.1007/s13346-013-0174-7
Hussain, MJ, Wilkinson, A, Bramwell, VW, Christensen, D & Perrie, Y 2014, 'Th1 immune responses can be modulated by varying dimethyldioctadecylammonium and distearoyl-sn-glycero-3-phosphocholine content in liposomal adjuvants' Journal of Pharmacy and Pharmacology, vol. 66, no. 3, pp. 358-366. DOI:10.1111/jphp.12173
Wilkhu, JS, Ouyang, D, Kirchmeier, MJ, Anderson, DE & Perrie, Y 2014, 'Investigating the role of cholesterol in the formation of non-ionic surfactant based bilayer vesicles: thermal analysis and molecular dynamics' International Journal of Pharmaceutics, vol. 461, no. 1-2, pp. 331-341. DOI:10.1016/j.ijpharm.2013.11.063
Kaur, R, Henriksen-Lacey, M, Wilkhu, J , Devitt, A , Christensen, D & Perrie, Y 2014, ' Effect of incorporating cholesterol into DDA:TDB liposomal adjuvants on Bilayer properties, biodistribution, and immune responses ' Molecular pharmaceutics , vol 11, no. 1, pp. 197-207., 10.1021/mp400372j
Kaur, R, Henriksen-Lacey, M, Wilkhu, J, Devitt, A, Christensen, D & Perrie, Y 2014, 'Effect of incorporating cholesterol into DDA:TDB liposomal adjuvants on Bilayer properties, biodistribution, and immune responses' Molecular Pharmaceutics, vol. 11, no. 1, pp. 197-207. DOI:10.1021/mp400372j
Stokes, CA, Glanville, N, Kaur, R, Hume, RD, Robinson, D, Perrie, Y, Edwards, MR, O' Donnell, V, Harwood, J, Parker, LC & Sabroe, I 2013, 'Phosphatidylserine-containing liposomes: modulators of rhinovirus induced inflammatory responses' Immunology, vol. 140, no. S1, 287, pp. 108. DOI:10.1111/imm.12184
Perrie, Y, Kaur, R & Henriksen-Lacey, M 2013,Vaccines. in IF Uchegbu, AG Schätzlein, WP Cheng & A Lalatsa (eds),Fundamentals of pharmaceutical nanoscience.Springer, New York (US), pp. 465-491. DOI:10.1007/978-1-4614-9164-4_17
Ali, MH, Moghaddam, B, Kirby, DJ , Mohammed, AR & Perrie, Y 2013, 'The role of lipid geometry in designing liposomes for the solubilisation of poorly water soluble drugs' International Journal of Pharmaceutics, vol. 453, no. 1, pp. 225-232. DOI:10.1016/j.ijpharm.2012.06.056
Perrie, Y, Kastner, E, Kaur, R, Wilkinson, A & Ingham, AJ 2013, 'A case-study investigating the physicochemical characteristics that dictate the function of a liposomal adjuvant' Human Vaccines and Immunotherapeutics, vol. 9, no. 6, pp. 1374-1381. DOI:10.4161/hv.24694
Khan, S, Batchelor, H, Hanson, P, Saleem, IY, Perrie, Y & Mohammed, AR 2013, 'Dissolution rate enhancement, in vitro evaluation and investigation of drug release kinetics of chloramphenicol and sulphamethoxazole solid dispersions' Drug Development and Industrial Pharmacy, vol. 39, no. 5, pp. 704-715. DOI:10.3109/03639045.2012.689763
Wilkhu, JS, McNeil, SE, Anderson, DE & Perrie, Y 2013, 'Characterization and optimization of bilosomes for oral vaccine delivery' Journal of Drug Targeting, vol. 21, no. 3, pp. 291-299. DOI:10.3109/1061186X.2012.747528
Wilson, KA & Perrie, Y 2013, 'Pharmacy (ISSN 2226-4787): a journal of pharmacy education and practice' Pharmacy, vol. 1, no. 1, pp. 1-2. DOI:10.3390/pharmacy1010001
Flower, DR & Perrie, Y 2013,Immunomic discovery of adjuvants, delivery systems, and candidate subunit vaccines: A brief introduction. inImmunomic Discovery of Adjuvants and Candidate Subunit Vaccines.Immunomics Reviews, vol. 5, Springer, pp. 1-11. DOI:10.1007/978-1-4614-5070-2_1
Flower, DR & Perrie, Y 2013,Preface. inImmunomic Discovery of Adjuvants and Candidate Subunit Vaccines.Immunomics Reviews, vol. 5, Springer, pp. v. DOI:10.1007/978-1-4614-5070-2
Daneshpour, N, Collighan, R , Perrie, Y , Lambert, P , Rathbone, D , Lowry, D & Griffin, M 2013, 'Indwelling catheters and medical implants with FXIIIa inhibitors: a novel approach to the treatment of catheter and medical device-related infections' European Journal of Pharmaceutics and Biopharmaceutics, vol. 83, no. 1, pp. 106–113. DOI:10.1016/j.ejpb.2012.09.005
Kirby, DJ, Kaur, R, Agger, EM, Andersen, P, Bramwell, VW & Perrie, Y 2013, 'Developing solid particulate vaccine adjuvants: surface bound antigen favouring a humoural response, whereas entrapped antigen shows a tendency for cell mediated immunity' Current Drug Delivery, vol. 11, no. 6, pp. 268-278. DOI:10.2174/1567201811310030003
Kaur, R, Bramwell, VW, Kirby, DJ & Perrie, Y 2012, 'Manipulation of the surface pegylation in combination with reduced vesicle size of cationic liposomal adjuvants modifies their clearance kinetics from the injection site, and the rate and type of T cell response' Journal of Controlled Release, vol. 164, no. 3, pp. 331-337. DOI:10.1016/j.jconrel.2012.07.012
Perrie, Y , Singh Badhan, R , Kirby, DJ , Lowry, D , Mohammed, A-U-R & Ouyang, D 2012, 'The impact of ageing on the barriers to drug delivery' Journal of Controlled Release, vol. 161, no. 2, pp. 389-398. DOI:10.1016/j.jconrel.2012.01.020
Christensen, D, Henriksen-Lacey, M, Kamath, AT, Lindenstrøm, T, Korsholm, KS, Christensen, JP, Rochat, A-F, Lambert, P-H, Andersen, P, Siegrist, C-A, Perrie, Y & Agger, EM 2012, 'A cationic vaccine adjuvant based on a saturated quaternary ammonium lipid have different in vivo distribution kinetics and display a distinct CD4 T cell-inducing capacity compared to its unsaturated analog' Journal of Controlled Release, vol. 160, no. 3, pp. 468-476. DOI:10.1016/j.jconrel.2012.03.016
Bibi, S, Lattmann, E , Mohammed, A-U-R & Perrie, Y 2012, 'Trigger release liposome systems: local and remote controlled delivery?' Journal of Microencapsulation, vol. 29, no. 3, pp. 262-276. DOI:10.3109/02652048.2011.646330
Milicic, A, Kaur, R, Reyes-Sandoval, A, Tang, C-K, Honeycutt, J, Perrie, Y & Hill, AVS 2012, 'Small cationic DDA: TDB liposomes as protein vaccine adjuvants obviate the need for TLR agonists in inducing cellular and humoral responses' PLoS ONE, vol. 7, no. 3, e34255. DOI:10.1371/journal.pone.0034255
Kaur, R, Bramwell, VW, Kirby, DJ & Perrie, Y 2012, 'Pegylation of DDA: TDB liposomal adjuvants reduces the vaccine depot effect and alters the Th1/Th2 immune responses' Journal of Controlled Release, vol. 158, no. 1, pp. 72-77. DOI:10.1016/j.jconrel.2011.10.012
Henriksen-Lacey, M, Christensen, D, Bramwell, VW, Lindenstrøm, T, Agger, EM, Andersen, P & Perrie, Y 2011, 'Comparison of the depot effect and immunogenicity of liposomes based on dimethyldioctadecylammonium (DDA), 3ß-[N-(N' ,N' -Dimethylaminoethane)carbomyl] cholesterol (DC-Chol), and 1,2-Dioleoyl-3-trimethylammonium propane (DOTAP): prolonged liposome retention mediates stronger Th1 responses' Molecular Pharmaceutics, vol. 8, no. 1, pp. 153-161. DOI:10.1021/mp100208f
Bibi, S, Kaur, R, Henriksen-Lacey, M, McNeil, SE, Wilkhu, J, Lattmann, E, Christensen, D, Mohammed, A-U-R & Perrie, Y 2011, 'Microscopy imaging of liposomes: from coverslips to environmental SEM' International Journal of Pharmaceutics, vol. 417, no. 1-2, pp. 138-150. DOI:10.1016/j.ijpharm.2010.12.021
Moghaddam, B, McNeil, SE, Zheng, Q, Mohammed, AR & Perrie, Y 2011, 'Exploring the correlation between lipid packaging in lipoplexes and their transfection efficacy' Pharmaceutics, vol. 3, no. 4, pp. 848-864. DOI:10.3390/pharmaceutics3040848
Al Husban, F, Perrie, Y & R. Mohammed, A-U-R 2011, 'Formulation of multiparticulate systems as lyophilised orally disintegrating tablets' European Journal of Pharmaceutics and Biopharmaceutics, vol. 79, no. 3, pp. 627-634. DOI:10.1016/j.ejpb.2011.05.014
Khan, S, Batchelor, H, Hanson, P , Perrie, Y & Mohammed, A-U-R 2011, 'Physicochemical characterisation, drug polymer dissolution and in vitro evaluation of phenacetin and phenylbutazone solid dispersions with polyethylene glycol 8000' Journal of Pharmaceutical Sciences, vol. 100, no. 10, pp. 4281-4294. DOI:10.1002/jps.22613
Khan, S, Elshaer, A, Rahman, AS, Hanson, P , Perrie, Y & Mohammed, A-U-R 2011, 'Systems biology approach to study permeability of paracetamol and its solid dispersion' International Journal of Pharmaceutics, vol. 417, no. 1-2, pp. 272-279. DOI:10.1016/j.ijpharm.2010.12.029
Perrie, Y & Rades, T 2011, 'Advanced characterisation techniques' International Journal of Pharmaceutics, vol. 417, no. 1-2, pp. 1-2. DOI:10.1016/j.ijpharm.2011.03.036
Moghaddam, B, Ali, H, Wilkhu, J, Kirby, DJ , Mohammed, A-U-R, Zheng, Q & Perrie, Y 2011, 'The application of monolayer studies in the understanding of liposomal formulations' International Journal of Pharmaceutics, vol. 417, no. 1-2, pp. 235-244. DOI:10.1016/j.ijpharm.2011.01.020
Henriksen-Lacey, M, Devitt, A & Perrie, Y 2011, 'The vesicle size of DDA: TDB liposomal adjuvants plays a role in the cell-mediated immune response but has no significant effect on antibody production' Journal of Controlled Release, vol. 154, no. 2, pp. 131-137. DOI:10.1016/j.jconrel.2011.05.019
Daneshpour, N, Griffin, M , Collighan, R & Perrie, Y 2011, 'Targeted delivery of a novel group of site-directed transglutaminase inhibitors to the liver using liposomes: a new approach for the potential treatment of liver fibrosis' Journal of Drug Targeting, vol. 19, no. 8, pp. 624-631. DOI:10.3109/1061186X.2010.531731
Wilkhu, J, McNeil, SE, Kirby, DJ & Perrie, Y 2011, 'Formulation design considerations for oral vaccines' Therapeutic Delivery, vol. 2, no. 9, pp. 1141-1164. DOI:10.4155/tde.11.82
Khan, S, Elshaer, A, Rahman, AS, Hanson, P , Perrie, Y & Mohammed, A-U-R 2011, 'Genomic evaluation during permeability of indomethacin and its solid dispersion' Journal of Drug Targeting, vol. 19, no. 8, pp. 615-623. DOI:10.3109/1061186X.2010.531730
Jones, RJ, Rajabi-Siahboomi, A, Levina, M, Perrie, Y & Mohammed, AR 2011, 'The influence of formulation and manufacturing process parameters on the characteristics of lyophilized orally disintegrating tablets' Pharmaceutics, vol. 3, no. 3, pp. 440-457. DOI:10.3390/pharmaceutics3030440
McNeil, SE, Griffiths, HR & Perrie, Y 2011, 'Polycaprolactone fibres as a potential delivery system for collagen to support bone regeneration' Current Drug Delivery, vol. 8, no. 4, pp. 448-455.
Kaur, R, Chen, J, Dawoodji, A, Cerundolo, V, Garcia-Diaz, YR, Wojno, J, Cox, LR, Besra, GS, Moghaddam, B & Perrie, Y 2011, 'Preparation, characterisation and entrapment of a non-glycosidic threitol ceramide into liposomes for presentation to invariant natural killer T cells' Journal of Pharmaceutical Sciences, vol. 100, no. 7, pp. 2724-2733. DOI:10.1002/jps.22500
Carstens, MG, Camps, MGM, Henriksen-Lacey, M, Franken, K, Ottenhoff, THM, Perrie, Y, Bouwstra, JA, Ossendorp, F & Jiskoot, W 2011, 'Effect of vesicle size on tissue localization and immunogenicity of liposomal DNA vaccines' Vaccine, vol. 29, no. 29-30, pp. 4761-70. DOI:10.1016/j.vaccine.2011.04.081
McNeil, SE, Rosenkrands, I, Agger, EM, Andersen, P, Perrie, Y & Agger, EM 2011, 'Subunit vaccines distearoylphosphatidylcholine-based liposomes entrapping antigen offer a neutral alternative to dimethyldioctadecylammonium-based cationic liposomes as an adjuvant delivery system' Journal of Pharmaceutical Sciences, vol. 100, no. 5, pp. 1856-1865. DOI:10.1002/jps.22427
Henriksen-Lacey, M, Korsholm, KS, Andersen, P, Perrie, Y & Christensen, D 2011, 'Liposomal vaccine delivery systems' Expert Opinion on Drug Delivery, vol. 8, no. 4, pp. 505-519. DOI:10.1517/17425247.2011.558081
Shabir, A, Alhusban, F, Perrie, Y & Mohammed, AR 2011, 'Effects of ball-milling on PLGA polymer and its implication on lansoprazole-loaded nanoparticles' Journal of Basic and Clinical Pharmacy, vol. 2, no. 2, pp. 71-82.
Mohanan, D, Slütter, B, Henriksen-Lacey, M, Jiskoot, W, Bouwstra, JA, Perrie, Y, Kündig, TM, Gander, B & Johansen, P 2010, 'Administration routes affect the quality of immune responses: a cross-sectional evaluation of particulate antigen-delivery systems' Journal of Controlled Release, vol. 147, no. 3, pp. 342-349. DOI:10.1016/j.jconrel.2010.08.012
R Mohammed, A-U-R, Bramwell, VW, Kirby, DJ, McNeil, SE & Perrie, Y 2010, 'Increased potential of a cationic liposome-based delivery system: enhancing stability and sustained immunological activity in pre-clinical development' European Journal of Pharmaceutics and Biopharmaceutics, vol. 76, no. 3, pp. 404-412. DOI:10.1016/j.ejpb.2010.09.008
Perrie, Y & Rades, T 2010, 'Themed issue: improve dissolution, solubility and bioavailability of poorly soluble drugs' Journal of Pharmacy and Pharmacology, vol. 62, no. 11, pp. 1517-1518. DOI:10.1111/j.2042-7158.2010.01199.x
Ali, H, Kirby, DJ , Mohammed, A-U-R & Perrie, Y 2010, 'Solubilisation of drugs within liposomal bilayers: alternatives to cholesterol as a membrane stabilising agent' Journal of Pharmacy and Pharmacology, vol. 62, no. 11, pp. 1646-1655. DOI:10.1111/j.2042-7158.2010.01090.x
Henriksen-Lacey, M, Christensen, D, Bramwell, VW, Lindenstrøm, T, Agger, EM, Andersen, P & Perrie, Y 2010, 'Liposomal cationic charge and antigen adsorption are important properties for the efficient deposition of antigen at the injection site and ability of the vaccine to induce a CMI response' Journal of Controlled Release, vol. 145, no. 2, pp. 102-108. DOI:10.1016/j.jconrel.2010.03.027
Al Husban, F, Perrie, Y & Mohammed, AR 2010, 'Formulation and characterisation of lyophilised rapid disintegrating tablets using amino acids as matrix forming agents' European Journal of Pharmaceutics and Biopharmaceutics, vol. 75, no. 2, pp. 254-262. DOI:10.1016/j.ejpb.2010.03.012
Mohammed, A-U-R & Perrie, Y 2010,A freeze-dried tablet, Patent No. GB 1005976.4, IPC No. A61K9/00.
McNeil, SE, Vangala, A, Bramwell, VW, Hanson, PJ & Perrie, Y 2010, 'Lipoplexes formulation and optimisation: in vitro transfection studies reveal no correlation with in vivo vaccination studies' Current Drug Delivery, vol. 7, no. 2, pp. 175-187. DOI:10.2174/156720110791011774
Henriksen-Lacey, M, Bramwell, V & Perrie, Y 2010, 'Radiolabelling of antigen and liposomes for vaccine biodistribution studies' Pharmaceutics, vol. 2, no. 2, pp. 91-104. DOI:10.3390/pharmaceutics2020091
Henriksen-Lacey, M, Bramwell, VW, Christensen, D, Agger, EM, Andersen, P & Perrie, Y 2010, 'Liposomes based on dimethyldioctadecylammonium promote a depot effect and enhance immunogenicity of soluble antigen' Journal of Controlled Release, vol. 142, no. 2, pp. 180-186. DOI:10.1016/j.jconrel.2009.10.022
Smith, AM, Ingham, A, Grover, LM & Perrie, Y 2010, 'Polymer film formulations for the preparation of enteric pharmaceutical capsules' Journal of Pharmacy and Pharmacology, vol. 62, no. 2, pp. 167-172. DOI:10.1211/jpp.62.02.0003
AlHusban, F, Elshaer, AM, Kansara, JH, Smith, AM, Grover, LM, Perrie, Y & Mohammed, A-U-R 2010, 'Investigation of formulation and process of lyophilised orally disintegrating tablet (ODT) using novel amino acid combination' Pharmaceutics, vol. 2, no. 1, pp. 1-17. DOI:10.3390/pharmaceutics2010001
AlHusban, F, Perrie, Y & Mohammed, AR 2010, 'Preparation, optimisation and characterisation of lyophilised rapid disintegrating tablets based on gelatin and saccharide' Current Drug Delivery, vol. 7, no. 1, pp. 65-75.
Perrie, Y, Ali, H, Kirby, DJ , Mohammed, AUR, McNeil, SE & Vangala, A 2010,Environmental scanning electron microscope imaging of vesicle systems. in V Weissig (ed.),Liposomes: methods and protocols : biological membrane models.vol. 2, Methods in molecular biology, vol. 606, pp. 319-331. DOI:10.1007/978-1-60761-447-0_21
Henriksen-Lacey, M, Christensen, D, Agger, EM, Andersen, P, Devitt, A & Perrie, Y 2010, 'Cationic liposomes as adjuvants for subunit protein vaccines: their role in the depot effect and antigen processing by APCs' 11th International Symposium on Dendritic Cells in fundamental and Clinical Immunology - DC2010:Forum on Vaccine Science, Lugano, Switzerland,26/09/10 -30/09/10 , .
Chang, H-I, Wang, Y, Perrie, Y & Coombes, AGA 2010, 'Microporous polycaprolactone matrices for drug delivery and tissue engineering: the release behaviour of bioactives having extremes of aqueous solubility' Journal of Drug Delivery Science and Technology, vol. 20, no. 3, pp. 207-212. DOI:10.1016/S1773-2247(10)50031-5
Christensen, D, Korsholm, K, Wood, GK, Mohammed, A, Bramwell, V, Andersen, P, Agger, EM & Perrie, Y 2009,Liposomes in adjuvant systems for parenteral delivery of vaccines. in L Jorgensen & H Mørck Nielsen (eds),Delivery technologies for biopharmaceuticals: peptides, proteins, nucleic acids and vaccines.Wiley, Chirchester (UK), pp. 359-376. DOI:10.1002/9780470688397.ch18
Kaur, R, Morris, R, Bencsik, M, Vangala, A, Rades, T & Perrie, Y 2009, 'Development of a novel magnetic resonance imaging contrast agent for pressure measurements using lipid-coated microbubbles' Journal of Biomedical Nanotechnology, vol. 5, no. 6, pp. 707-715. DOI:10.1166/jbn.2009.1087
Mohammed, A-U-R, AlHusban, F & Perrie, Y 2009,Disintegrating tablets, Patent No. GB 0920041.1, IPC No. A61K9/20.
Perrie, Y & Mohammed, A-U-R 2009, 'Pharmaceutics: a new open-access journal for all those interested in designing medicines' Pharmaceutics, vol. 1, no. 1, pp. 1-2. DOI:10.3390/pharmaceutics1010001
Bhowruth, V, Minnikin, DE, Agger, EM, Andersen, P, Bramwell, VW, Perrie, Y & Besra, GS 2009, 'Adjuvant properties of a simplified C₃₂monomycolyl glycerol analogue' Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 7, pp. 2029-2032. DOI:10.1016/j.bmcl.2009.02.027
Hofmann, MP, Mohammed, AR , Perrie, Y, Gbureck, U & Barralet, JE 2009, 'High-strength resorbable brushite bone cement with controlled drug-releasing capabilities' Acta Biomaterialia, vol. 5, no. 1, pp. 43-49. DOI:10.1016/j.actbio.2008.08.005
Christensen, D, Agger, EM, Andreasen, LV, Kirby, D, Andersen, P & Perrie, Y 2009, 'Liposome-based cationic adjuvant formulations (CAF): past, present, and future' Journal of Liposome Research, vol. 19, no. 1, pp. 2-11. DOI:10.1080/08982100902726820
Perrie, Y 2009, 'Liposomes, lipid assemblies, nanotechnology, and everything interesting in between' Journal of Liposome Research, vol. 19, no. 1. DOI:10.1080/08982100902748980
Perrie, Y , Mohammed, AR , Kirby, DJ, McNeil, SE & Bramwell, VW 2008, 'Vaccine adjuvant systems: enhancing the efficacy of sub-unit protein antigens' International Journal of Pharmaceutics, vol. 364, no. 2, pp. 272-280. DOI:10.1016/j.ijpharm.2008.04.036
Morris, R, Bencsik, M, Nestle, N, Kaur, R, Galvosas, P & Perrie, Y 2008,MRI pressure and stress measurement in novel homogeneous soft solids. in MD Hürlimann, YQ Song , P Fantazzini & V Bortolotti (eds),Magnetic resonance in porous media: proceedings of the 9th international Bologna conference on magnetic resonance in porous media (MRPM9), including 8th colloquium on mobile magnetic resonance (CMMR8).AIP conference proceedings, vol. 1081, AIP, pp. 63-66, 9th International Bologna Conference on Magnetic Resonance in Porous Media, including 8th Colloquium on Mobile Magnetic Resonance, Cambridge, MA, United States, 13-17 July. DOI:10.1063/1.3058548
Hofmann, MP, Mohammed, AR , Perrie, Y, Gbureck, U & Barralet, JE 2008,High strength resorbable brushite bone cement with controlled drug releasing capabilities. in8th World Biomaterials Congress 2008.vol. 4, 8th World Biomaterials Congress 2008, WBC 2008, Amsterdam, United Kingdom, 28-1 June.
Clark, S, Cross, ML, Smith, A, Court, P, Vipond, J, Nadian, A, Hewinson, RG, Batchelor, HK, Perrie, Y, Williams, A, Aldwell, FE & Chambers, MA 2008, 'Assessment of different formulations of oral Mycobacterium bovis Bacille Calmette-Guerin (BCG) vaccine in rodent models for immunogenicity and protection against aerosol challenge with M-bovis' Vaccine, vol. 26, no. 46, pp. 5791-5797. DOI:10.1016/j.vaccine.2008.08.028
Morris, RH, Bencsik, M, Nestle, N, Galvosas, P, Fairhurst, D, Vangala, A, Perrie, Y & McHale, G 2008, 'Robust spatially resolved pressure measurements using MRI with novel buoyant advection-free preparations of stable microbubbles in polysaccharide gels' Journal of Magnetic Resonance, vol. 193, no. 2, pp. 159-167. DOI:10.1016/j.jmr.2008.04.025
Christensen, D, Kirby, D, Foged, C, Agger, EM, Andersen, P, Perrie, Y & Nielsen, HM 2008, 'aa' -trehalose 6,6' -dibehenate in non-phospholipid-based liposomes enables direct interaction with trehalose, offering stability during freeze-drying' BBA -Biomembranes, vol. 1778, no. 5, pp. 1365-1373. DOI:10.1016/j.bbamem.2008.01.013
Kirby, DJ, Rosenkrands, I, Agger, EM, Andersen, P, Coombes, AGA & Perrie, Y 2008, 'PLGA microspheres for the delivery of a novel subunit TB vaccine' Journal of Drug Targeting, vol. 16, no. 4, pp. 282-293. DOI:10.1080/10611860801900462
Kirby, DJ, Rosenkrands, I, Agger, EM, Andersen, P, Coombes, AGA & Perrie, Y 2008, 'Liposomes act as stronger sub-unit vaccine adjuvants when compared to microspheres' Journal of Drug Targeting, vol. 16, no. 7-8, pp. 543-554. DOI:10.1080/10611860802228558
Perrie, Y 2008, 'Gregory Gregoriadis: introducing liposomes to drug delivery' Journal of Drug Targeting, vol. 16, no. 7-8, pp. 518-519. DOI:10.1080/10611860802228376