Dr Dan Rathbone

Senior Lecturer in Pharmaceutical Sciences 

PG Pharmacy Taught Programmes Director 

School of Life & Health Sciences
Aston University
, Aston Triangle
Birmingham, B4 7ET, UK
 

Telephone: +44 (0) 121 204 4002

Room: MB357D

Email: D.L.Rathbone@aston.ac.uk

Research Group

Molecular Biomedical Research

Research Centre

Aston Research Centre for Healthy Ageing (ARCHA)
Dan Rathbone 004
I became a lecturer in pharmaceutical sciences in the Aston School of Pharmacy in 1999. Prior to that I had undertaken postdoctoral research in synthetic chemistry at Bonn and Aston as well as nearly six years working for a contract research company. My research interests have broadened out from synthetic chemistry to include molecular modelling and drug design. The current focus is on the design and synthesis of antimicrobial compounds, tissue transglutaminase inhibitors and the application of computational methods to pharmaceutical formulations.

1984-87 PhD, University of Warwick
1980-84 BA, Chemistry, St. Edmund Hall, University of Oxford

2007 to date  Senior Lecturer, Aston University
1999-2007 Lecturer in Pharmaceutical Sciences, Aston University
1996-99 Research Fellow, Aston University
1990-95 Senior Chemist, Aston Molecules Ltd
1989 Postdoctoral Fellow, Warwick University
1988 Postdoctoral Fellow, Institut fur Organische Chemie und Biochemie, Bonn

  • MPharm course - medicinal chemistry and drug design
  • BSc Biochemistry – Biological chemistry
  • BSc Biological Sciences – Biochemistry
  • MSc courses – various aspect of drug discovery
  • Design, synthesis and screening of libraries of new antibacterial compounds
  • Protein modelling and computer aided drug design
  • Design and synthesis of transglutaminase inhibitors

Member of the Royal Society of Chemistry

Fellow of the Higher Education Academy

  • Design and synthesis of inhibitors of New Delhi β‑lactamase 
  • Design and synthesis of inhibitors of mycobacterial β‑lactamases
  • Design and synthesis of inhibitors of tissue transglutaminase
  • Surfaces for the elimination of Clostridium difficile
  • Molecular simulation of drug behaviour and release from formulated products
  • Computational investigation of potential inhibitors of New Delhi β‑lactamase
  • Design and synthesis of inhibitors of tissue transglutaminase
  • Design and synthesis of inhibitors of microbial b-lactamases (student starting on 1st April)
  • Surfaces for the elimination of Clostridium difficile (Studentship advertised)

Recent Publications

Rachel Huey, Dan Rathbone, Paul McCarron & Susan Hawthorne, 2019, Design, stability and efficacy of a new targeting peptide for nanoparticulate drug delivery to SH-SY5Y neuroblastoma cells, Journal of Drug Targeting, Accepted author version posted online: 09 Jan 2019, Published online: 31 Jan 2019, https://doi.org/10.1080/1061186X.2019.1567737