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Aston Brain Centre
Aston Research centre in CHildren and Young people's health(ARCHY)
PH2501: Antidysrhythmic drugs. PH3601: Glutamate, drug abuse, epilepsy, general aAnaesthetics, learning and memory, excitotoxicity. PH4705: Neuronal networks.
Electrophysiological studies on neurones of the entorhinal cortex (EC).
The role of presynaptic metabotropic glutamate and NMDA receptors in epilepsy in the EC
The role of cannabinoids in the EC
The role of primary motor cortex in epilepsy and Parkinson’s disease (in collaboration with Dr. Ian Stanford and Dr. Stephen Hall).
The EC is part of the temporal lobe, a brain region which is especially prone to epilepsy. My research focuses on how epilepsy leads to changes the presynaptic control of neurotransmitter release onto neurones in the deep and superficial layers of the EC, and on the relationship between control of action potential evoked and action potential independent release of glutamate and GABA. I am also interested in the role of presynaptic CB1 cannabinoid receptors in control of GABA release in the normal and chronically epileptic EC. I am currently setting up a human tissue laboratory to investigate these questions in human brain slices.
I am also interested in primary motor cortex (M1), and am currently investigating neuronal network oscillations in this area, with a view to understanding how activity in M1 is altered through synaptic plasticity in epilepsy and Parkinson’s disease. These experiments are complemented by investigations in man via MEG studies (Steve Hall).
Dr. Roland Jones (University of Bath)
Glutamate Induced Glutamate release in medial entorhinal cortex
Synaptogenesis following epileptogenesis in the rat medial temporal lobe
Chronic changes in presynaptic function following epileptogenesis in the rat medial temporal lobe
Development of a reduced severity epilepsy model in the rat
Effects of Zolpidem and other ligands on spontaneous inhibitory postsynaptic currents and intenruonal oscillatory activity
MEG analysis of the cognitive effects of zolpidem
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