The Oxidative Stress and Proteomics group led by Dr Corinne Spickett and Professor Andrew Pitt of Aston University and their research team will join researchers from Glasgow University and Imperial College London to showcase a range of new technologies being developed to study single cells and explain why the science of individual cells is important. The universities are all part of the EPSRC funded interdisciplinary Proxomics project.
The Aston team is developing methods to understand how proteins in the cell change and interact differently with each other when cells become stressed, a common event in many diseases, which in turn could hold vital clues for cancer therapeutics and personalised healthcare. Their display on “all the wrong signals” demonstrates how proteins send different signals in cancer cells through modified protein-protein interactions. The Single Cell Science exhibit will reveal why these small differences in cells matter, how they can be studied, and how this could lead to the development of new drug treatments.
The Oxidative Stress and Proteomics group said: “Cells of the same type in a population – such as in an organ of the body – can behave differently in response to the same signal. In some cases the different behaviour can lead to disease. We use cutting edge techniques to separate individual cells, and measure their unique response by studying what proteins, and how much of them, are present within them. This ‘protein fingerprint’ can reveal hidden interactions between molecular pathways in the cell, and aid the discovery of new drugs.”
The Royal Society event, involving ‘hands-on’ exhibitions, is designed to showcase the UK's most exciting new developments in science and technology.
Entry is free for visitors of all ages, with the exhibition running from Tuesday 30 June until Sunday 5 July 2015. Visit the Royal Society website for more information about venue, times and location.
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